Osteoporosis Research Center, Presidio Sanitario San Camillo, Strada Santa Margherita 136, 10131 Torino, Italy.
Arch Gerontol Geriatr. 2011 Jan-Feb;52(1):71-4. doi: 10.1016/j.archger.2010.02.002. Epub 2010 Mar 5.
Changes in body composition, including a decrease in muscle and bone mass, accompany aging. Our aim was to assess the prevalence of sarcopenia and its association with osteoporosis in hip-fracture women. We performed a Dual-Energy X-Ray Absorptiometry (DXA) scan in 313 of 340 women, 20.9 ± 6.5 (mean ± S.D.) days after hip-fracture occurrence. To adjust appendicular lean mass for body size we divided it by height squared in each woman. A total of 180 of the 313 women (58%) were sarcopenic, whereas 230 (74%) were osteoporotic. After adjustment for age and interval between fracture and DXA scan we found a significant association between sarcopenia and osteoporosis (p=0.026). For a sarcopenic woman the adjusted odds ratio (OR) for osteoporosis was 1.80 (95%CI=1.07-3.02). Our data shows the high prevalence of sarcopenia and its significant association with osteoporosis in a large sample of hip-fracture women. Data supports a research approach on preventive and treatment strategies for osteoporosis and sarcopenia targeting both bone and muscle tissue. Furthermore, data should be considered when the economic burden of sarcopenia is estimated, given the high proportion of sarcopenic women with bone fragility.
身体成分的变化，包括肌肉和骨量的减少，伴随着衰老。我们的目的是评估髋部骨折女性中肌少症的患病率及其与骨质疏松症的关系。我们对 340 名女性中的 313 名（20.9 ± 6.5 [均值 ± 标准差] 天）在髋部骨折发生后进行了双能 X 射线吸收法（DXA）扫描。为了根据身体大小调整四肢瘦体重，我们将其除以每位女性的身高平方。313 名女性中共有 180 名（58%）患有肌少症，而 230 名（74%）患有骨质疏松症。在调整年龄和骨折与 DXA 扫描之间的时间间隔后，我们发现肌少症与骨质疏松症之间存在显著关联（p=0.026）。对于患有肌少症的女性，骨质疏松症的调整后优势比（OR）为 1.80（95%CI=1.07-3.02）。我们的数据表明，在大量髋部骨折女性中，肌少症的患病率很高，且与骨质疏松症有显著关联。数据支持针对骨骼和肌肉组织的骨质疏松症和肌少症的预防和治疗策略的研究方法。此外，鉴于存在大量患有骨骼脆弱症的肌少症女性，在估计肌少症的经济负担时应考虑到这些数据。
