Osteoporosis Research Center, Division of Physical Medicine and Rehabilitation, Presidio Sanitario San Camillo, Strada Santa Margherita 136, 10131 Torino, Italy.
Arch Gerontol Geriatr. 2012 Sep-Oct;55(2):e48-52. doi: 10.1016/j.archger.2012.05.002. Epub 2012 May 28.
Our aim was to compare the prevalence of sarcopenia in men and women with hip fracture. We studied 591 of 630 hip fracture inpatients consecutively admitted to our Rehabilitation ward. All the patients underwent a Dual-Energy X-Ray Absorptiometry (DXA) scan 18.4 ± 8.7 (mean ± SD) days after hip fracture occurrence. Sarcopenia was defined when appendicular lean mass divided by height squared was less than two standard deviations below the mean of the young reference group obtained from population based studies. Using normative data from the New Mexico Elder Health Study, 340 of the 531 women (64.0%), and 57 of the 60 men (95.0%) had sarcopenia. Using normative data from the survey performed in Rochester, Minnesota, 116 of the 531 women (21.8%), and 52 of the 60 men (86.7%) had sarcopenia. After adjustment for age, time between fracture occurrence and DXA scan, number of medications in use, and number of concomitant diseases, men had a significantly higher prevalence of sarcopenia than women (p < 0.001). The adjusted odds ratio was either 10.54 (95% CI from 3.25 to 34.16) or 23.64 (from 10.8 to 51.6) depending on the reference population adopted. Our data shows a high proportion of sarcopenic subjects after hip-fracture. Sarcopenia was significantly more prevalent in men than in women. Relevancy of prevention and treatment of muscle loss is emphasized, particularly in men.
我们的目的是比较男性和女性髋部骨折患者中肌少症的患病率。我们连续研究了 630 例髋部骨折住院患者中的 591 例，这些患者均在髋部骨折发生后 18.4 ± 8.7（平均值 ± 标准差）天接受了双能 X 射线吸收法（DXA）扫描。当四肢瘦体重除以身高的平方值低于基于人群研究获得的年轻参考组平均值的两个标准差以下时，定义为肌少症。使用新墨西哥州老年人健康研究的参考数据，531 名女性中有 340 名（64.0%），60 名男性中有 57 名（95.0%）患有肌少症。使用明尼苏达州罗彻斯特进行的调查的参考数据，531 名女性中有 116 名（21.8%），60 名男性中有 52 名（86.7%）患有肌少症。在校正年龄、骨折发生与 DXA 扫描之间的时间、使用药物的数量和并存疾病的数量后，男性的肌少症患病率明显高于女性（p < 0.001）。调整后的优势比分别为 10.54（95%CI 为 3.25 至 34.16）或 23.64（来自 10.8 至 51.6），具体取决于采用的参考人群。我们的数据显示髋部骨折后肌少症患者的比例较高。男性肌少症的患病率明显高于女性。强调了预防和治疗肌肉减少症的相关性，特别是在男性中。
