Division of Urogynecology, Department of Obstetrics and Gynecology, University of Connecticut School of Medicine, Hartford Hospital, Hartford, CT 06106, USA.
Am J Obstet Gynecol. 2010 May;202(5):479.e1-5. doi: 10.1016/j.ajog.2010.01.003. Epub 2010 Mar 6.
The objective of the study was to compare time to first bowel movement (BM) after surgery in subjects randomized to placebo or senna with docusate.
Ninety-six subjects completed a baseline 7-day bowel diary before and after surgery. After pelvic reconstructive surgery, the subjects were randomized to either placebo (n=45) or senna (8.6 mg) with docusate (50 mg) (n=48). Time to first BM and postoperative use of magnesium citrate were compared.
There was a significant difference in the time to first BM in those receiving senna with docusate vs placebo (3.00+/-1.50 vs 4.05+/-1.50 days; P<.002). More subjects in the placebo group needed to use magnesium citrate to initiate a bowel movement (43.6% vs 7.0%; P<.001).
The use of senna with docusate decreases time to first BM in those undergoing pelvic reconstructive surgery compared with placebo. Subjects using senna with docusate are also significantly less likely to use magnesium citrate.
本研究旨在比较手术后首次排便（BM）时间，研究对象被随机分为安慰剂或番泻叶与多库酯钠组。
96 名受试者在手术前后完成了为期 7 天的基线排便日记。在骨盆重建手术后，受试者被随机分为安慰剂（n=45）或番泻叶（8.6mg）与多库酯钠（50mg）（n=48）组。比较首次 BM 时间和术后使用柠檬酸镁的情况。
使用番泻叶与多库酯钠的受试者首次 BM 时间与安慰剂组相比有显著差异（3.00+/-1.50 与 4.05+/-1.50 天；P<.002）。更多安慰剂组的受试者需要使用柠檬酸镁来启动排便（43.6% vs 7.0%；P<.001）。
与安慰剂相比，在接受骨盆重建手术的患者中，使用番泻叶与多库酯钠可缩短首次 BM 时间。使用番泻叶与多库酯钠的受试者也明显较少使用柠檬酸镁。
