Department of Neurology and Neuroscience, Weill Cornell Medical College/New York Presbyterian Hospital, 525 East 68th Street, New York, NY 10065-4885, USA.
J Neurol Sci. 2010 May 15;292(1-2):1-4. doi: 10.1016/j.jns.2010.02.016. Epub 2010 Mar 7.
The hepatitis B virus (HBV) is an important infectious cause of acute and chronic liver disease throughout the world. Recombinant hepatitis B vaccines have been developed to combat morbidity and mortality associated with HBV infection. These vaccines have been associated with autoimmune diseases mostly among adult vaccine recipients. Epidemiological surveys have not established unequivocal causality between the hepatitis B vaccine and the development of various autoimmune neuromuscular disorders. However, case histories and series hint at a temporal association between hepatitis B vaccines and the development of various neuropathy syndromes, polyarteritis nodosa complicated by vasculitic neuropathy, myasthenia gravis and dermatomyositis. Conceivably, the hepatitis B vaccines have a potential to occasionally trigger the onset of immune diseases in individuals with an underlying genetic or immunological susceptibility.
乙型肝炎病毒 (HBV) 是全球范围内引起急性和慢性肝脏疾病的重要传染性病原体。为了对抗乙型肝炎病毒感染相关的发病率和死亡率，已经开发了重组乙型肝炎疫苗。这些疫苗与自身免疫性疾病相关，主要发生在成年疫苗接种者中。流行病学调查并未明确确立乙型肝炎疫苗与各种自身免疫性神经肌肉疾病之间的因果关系。然而，病例报告和系列研究提示了乙型肝炎疫苗与各种神经病变综合征、结节性多动脉炎合并血管炎性神经病、重症肌无力和皮肌炎的发展之间存在时间上的关联。可以想象，乙型肝炎疫苗可能偶尔会在具有潜在遗传或免疫易感性的个体中引发免疫性疾病的发作。
