Seoul National University, College of Veterinary Medicine, Department of Veterinary Pathology, San 56-1, Shillim-Dong, Gwanak-Gu, Seoul 151-742, Republic of Korea.
Vet J. 2011 Apr;188(1):115-7. doi: 10.1016/j.tvjl.2010.02.006. Epub 2010 Mar 6.
The objective of this study was to determine the prevalence of porcine circovirus (PCV) type 2 genotypes in pigs with post-weaning multi-systemic wasting syndrome (PMWS) and in pigs that that did not have the disease. Nested PCR was used to analyse tissue from 540 formalin-fixed, paraffin-embedded lymph nodes. The number of PCV2a-positive pigs that had (χ(trend)(2)=54.584, P<0.001) and did not have (χ(trend)(2)=70.066, P<0.001) PMWS decreased significantly between the years 2000 and 2008. However, over this time-period, there was a significant increase in the number of animals infected with PCV2b that had (χ(trend)(2)=31.356, P<0.001) and did not have (χ(trend)(2)=9.494, P<0.001) PMWS. The findings demonstrate a significant overall increase in PCV2b infection in pigs that both have and do not have PMWS. Further studies will be required to determine the potential relationship between PCV2b infection and the increasing incidence of PMWS in Korea.
本研究旨在确定患有断奶后多系统消耗综合征（PMWS）和未患该病的猪中猪圆环病毒 2 型（PCV2）基因型的流行情况。采用巢式 PCR 分析了 540 份福尔马林固定、石蜡包埋的淋巴结组织。PCV2a 阳性猪的数量（χ(trend)(2)=54.584，P<0.001）和未患 PMWS 的猪（χ(trend)(2)=70.066，P<0.001）在 2000 年至 2008 年间显著减少。然而，在此期间，感染 PCV2b 的动物数量增加，无论是患有 PMWS 的动物（χ(trend)(2)=31.356，P<0.001）还是未患 PMWS 的动物（χ(trend)(2)=9.494，P<0.001）。研究结果表明，患有和不患有 PMWS 的猪中，PCV2b 感染总体显著增加。需要进一步研究来确定 PCV2b 感染与韩国 PMWS 发病率增加之间的潜在关系。
