Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul 151-742, Republic of Korea.
Res Vet Sci. 2010 Apr;88(2):333-8. doi: 10.1016/j.rvsc.2009.08.003. Epub 2009 Sep 9.
Porcine circovirus type 2 (PCV2) is the causative agent of postweaning multisystemic wasting syndrome (PMWS). In this study, 38 PCV2 cases obtained from different pig farms with different health conditions in Republic of Korea were sequenced and analyzed. Phylogenetic analysis showed that our cases had a greater variation and the existence of two PCV2 groups with at least four subgroups (1A, 1C, 2D, and 2E). Most cases obtained from PMWS-affected herds were in group 1, whereas cases with no clinical signs compatible with PMWS (wasted non-PMWS) were included within group 2. Moreover, four cases from the wasted non-PMWS belonged to PCV2-group 1. Therefore, our results suggest that PCV2-group 1 is more related to PMWS than group 2.
猪圆环病毒 2 型（PCV2）是断奶后多系统衰竭综合征（PMWS）的病原体。本研究对韩国不同健康状况的不同猪场的 38 个 PCV2 病例进行了测序和分析。系统进化分析表明，我们的病例存在更大的变异，并且存在至少 4 个亚群（1A、1C、2D 和 2E）的两个 PCV2 群。大多数来自 PMWS 感染群的病例属于第 1 组，而没有与 PMWS 临床症状相符（非 PMWS 消瘦）的病例则属于第 2 组。此外，4 例非 PMWS 消瘦病例属于 PCV2-1 组。因此，我们的结果表明，PCV2-1 组与 PMWS 的相关性高于 2 组。
