Physics Department, Tarbiat Modares University, Tehran, Iran.
Ultrason Sonochem. 2010 Jun;17(5):853-6. doi: 10.1016/j.ultsonch.2010.01.010. Epub 2010 Feb 12.
A rapid, environmental friendly and low-cost method to prepare hydroxyapatite nanoparticles is proposed. In this method, hydroxyapatite is produced in a sonicated pseudo-body solution. The sonication time was found effective in the formation of the crystalline phase of nanoparticles. In our experimental condition, 15 min sonication resulted in the most pure hydroxyapatite phase. Also it was shown that growth temperature is a crucial factor and hydroxyapatite crystallizes only at 37 degrees C. The particles formed by sonication were generally smaller and more spherical than those obtained without sonication. Sonication increased the hydroxyapatite crystal growth rate up to 5.5 times compared to non-sonication condition. The comparison between the specific surface area of hydroxyapatite nanoparticles obtained by sonication and without sonication demonstrated that sonication increased the specific surface area from 63 m(2)/g to 107 m(2)/g and decreased the size of nanoparticles from 30 nm to 18 nm. Analysis on the pore structure demonstrated that the fractal structures obtained with and without sonication were considerably different.
提出了一种快速、环保且低成本的方法来制备羟基磷灰石纳米粒子。在该方法中，在超声伪体液中制备羟基磷灰石。研究发现，超声时间对纳米晶相的形成有显著影响。在我们的实验条件下，15 分钟的超声处理可得到最纯的羟基磷灰石相。此外，还表明生长温度是一个关键因素，只有在 37°C 时才会结晶生成羟基磷灰石。与未经超声处理的相比，超声处理形成的颗粒通常更小且更圆。与未经超声处理的条件相比，超声处理将羟基磷灰石的晶体生长速率提高了 5.5 倍。对超声和未超声处理的羟基磷灰石纳米粒子的比表面积进行比较，结果表明，超声处理使比表面积从 63 m²/g 增加到 107 m²/g，纳米粒子的尺寸从 30nm 减小到 18nm。对孔结构的分析表明，有无超声处理得到的分形结构有很大的不同。
