Sealy R
Mersey Regional Centre for Radiotherapy and Oncology, Merseyside, U.K.
Radiother Oncol. 1991;20 Suppl 1:75-9. doi: 10.1016/0167-8140(91)90192-j.
Published reports on the use of hyperbaric oxygen in the radiation therapy of head and neck cancer are reviewed. The weight of evidence, from randomised trials, is that it is of clinical value in the control of medium sized head and neck tumours. It is also of value in the treatment of lymph node disease. Four attempts to improve the results of the treatment, by various physiological measures, are reviewed. It is concluded that hyperbaric oxygen may be of use when combined with nitroimidazoles as a radiation sensitiser and warrants further study when combined with induced anaemia, aimed to reduce the tumour cord and prevent repopulation between fractions.
本文综述了关于高压氧在头颈部癌症放射治疗中应用的已发表报告。来自随机试验的证据表明，它在控制中等大小的头颈部肿瘤方面具有临床价值。它在淋巴结疾病的治疗中也有价值。本文还综述了通过各种生理措施改善治疗效果的四次尝试。结论是，高压氧与硝基咪唑类药物联合作为放射增敏剂可能有用，与诱导性贫血联合使用以减少肿瘤细胞群并防止分次放疗期间的再增殖值得进一步研究。
