Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro, RJ 21040-900, Brazil.
Vet Rec. 2010 Mar 6;166(10):290-4. doi: 10.1136/vr.166.10.290.
The effectiveness and safety of treatment with ketoconazole and itraconazole were compared in 773 sporotrichosis-infected cats over a four-year period (2002 to 2005). Five hundred and ninety-eight cats received oral ketoconazole and 175 received oral itraconazole. Treatment was successful in 238 (30.8 per cent) cats, of which 171 (28.6 per cent) of 598 received 13.5 to 27.0 mg/kg/day ketoconazole and 67 (38.3 per cent) of 175 received 8.3 to 27.7 mg/kg/day itraconazole. Adverse effects were reported in 306 (39.6 per cent) of the cats, 105 (13.6 per cent) died and 430 (55.6 per cent) dropped out of treatment or were still under treatment at the time of data analysis.
在四年期间（2002 年至 2005 年），我们比较了酮康唑和伊曲康唑治疗孢子丝菌病的疗效和安全性。773 只患有孢子丝菌病的猫接受了口服酮康唑治疗，175 只接受了口服伊曲康唑治疗。238 只（30.8%）猫的治疗取得了成功，其中 598 只中接受 13.5 至 27.0 mg/kg/天酮康唑治疗的 171 只（28.6%）和 175 只中接受 8.3 至 27.7 mg/kg/天伊曲康唑治疗的 67 只（38.3%）。306 只（39.6%）猫出现了不良反应，105 只（13.6%）死亡，430 只（55.6%）在数据分析时退出治疗或仍在接受治疗。
