Beijing University of Science and Technology, People's Republic of China.
Biomed Mater. 2010 Apr;5(2):25003. doi: 10.1088/1748-6041/5/2/025003. Epub 2010 Mar 8.
Due to the non-bioactivity and poor conjunction performance of present cartilage prostheses, the main work here is to develop the bioactive glass-polyvinyl alcohol hydrogel articular cartilage/bone (BG-PVA/bone) composite implants. The essential criterion for a biomaterial to bond with living bone is well-matched mechanical properties as well as biocompatibility and bioactivity. In vitro studies on the formation of a surface layer of carbonate hydroxyl apatite (HCA) and the corresponding variation of the properties of biomaterials are imperative for their clinical application. In this paper, the mineralization behavior and variation of the interface properties of BG-PVA/bone composites were studied in vitro by using simulated body fluid (SBF). The mineralization and HCA layer formed on the interface between the BG-PVA hydrogel and bone in SBF could provide the composites with bioactivity and firmer combination. The compression property, shear strength and interface morphology of BG-PVA/bone composite implants varying with the immersion time in SBF were characterized. Also, the influence laws of the immersion time, content of BG in the composites and aperture of bones to the mineralization behavior and interface properties were investigated. The good mineralization behavior and enhanced conjunction performance of BG-PVA/bone composites demonstrated that this kind of composite implant might be more appropriate cartilage replacements.
由于现有软骨假体的非生物活性和连接性能差，本研究主要致力于开发生物活性玻璃-聚乙烯醇水凝胶关节软骨/骨（BG-PVA/骨）复合材料植入物。生物材料与活体骨结合的基本标准是具有良好的机械性能、生物相容性和生物活性。体外研究碳酸羟基磷灰石（HCA）表面层的形成以及生物材料性能的相应变化对于其临床应用是至关重要的。本文采用模拟体液（SBF）研究了 BG-PVA/骨复合材料的矿化行为及其界面性能的变化。在 SBF 中，BG-PVA 水凝胶与骨之间界面上形成的矿化和 HCA 层为复合材料提供了生物活性和更牢固的结合。对 BG-PVA/骨复合材料植入物在 SBF 中浸泡不同时间后的压缩性能、剪切强度和界面形态进行了表征。还研究了浸泡时间、复合材料中 BG 的含量和骨孔径对矿化行为和界面性能的影响规律。BG-PVA/骨复合材料具有良好的矿化行为和增强的连接性能，表明这种复合植入物可能更适合软骨替代物。
