Velikiĭ N N, Parkhomets P K, Turganbaeva T M, Chichkovskaia G V, Mogilevich S E
Vopr Med Khim. 1977 Nov-Dec(6):723-8.
Gluconeogenesis was stimulated in rat liver tissues if 38.5% of carbohydrates were substituted in the diet by 1,3-butane diol used as a source of energy. Under these conditions concentration of substrates (phosphoenol pyruvate, malate, oxalacetate), participating in coupling of glycolysis and gluconeogenesis, was increased in liver tissue; activity of gluconeogenesis key enzymes (phosphoenolpyruvate carboxykinase and fructose-1,6-diphosphatase) was also increased. Decrease in the ratio NAD+/NADH showed that the nicotinamide nucleotide pool acquired the most distinct reducing properties of cytoplasma and mitochondria of rats maintained on the diet. The value of phosphate potential (the ration ATP/ADP/Pn) was decreased during the experiment due to increase of ATP utilization in gluconeogenesis.
如果在大鼠肝脏组织的饮食中，用1,3 - 丁二醇作为能量来源替代38.5%的碳水化合物，糖异生作用会受到刺激。在这些条件下，参与糖酵解和糖异生偶联的底物（磷酸烯醇丙酮酸、苹果酸、草酰乙酸）在肝脏组织中的浓度会增加；糖异生关键酶（磷酸烯醇丙酮酸羧激酶和果糖 - 1,6 - 二磷酸酶）的活性也会增加。NAD⁺/NADH比值的降低表明，烟酰胺核苷酸池获得了食用该饮食的大鼠细胞质和线粒体最明显的还原特性。由于糖异生过程中ATP利用增加，实验过程中磷酸势（ATP/ADP/Pi比值）降低。
