[胸腺切除术对大鼠肝脏糖异生关键酶活性的影响]
[Effect of thymectomy on activity of key enzymes of gluconeogenesis in the rat liver].
作者信息
Podosinnikov I S, Zozuliakova S V, Chukhlovina M L, Polushkina L I, Zalkind L G
出版信息
Vopr Med Khim. 1987 Jan-Feb;33(1):29-33.
Activities of key enzymes of gluconeogenesis--phosphoenolpyruvate carboxykinase, fructose-1,6-diphosphatase, glucose-6-phosphatase as well as the content of glycogen were studied in liver tissue of thymectomized rats. Gluconeogenesis was inhibited in liver tissue of these rats. As thymus and adrenal cortex are firmly related, the inhibition of gluconeogenesis in liver tissue of thymectomized rats appears to occur due to a decrease in the glucocorticoid activating effect followed the inhibition of adrenal cortex functions and absence of thymus hormones directly responsible for carbohydrate metabolism.
在切除胸腺的大鼠肝脏组织中，研究了糖异生关键酶——磷酸烯醇丙酮酸羧激酶、果糖-1,6-二磷酸酶、葡萄糖-6-磷酸酶的活性以及糖原含量。这些大鼠的肝脏组织中糖异生受到抑制。由于胸腺与肾上腺皮质联系紧密，切除胸腺的大鼠肝脏组织中糖异生的抑制似乎是由于肾上腺皮质功能受到抑制后糖皮质激素激活作用减弱，以及缺乏直接负责碳水化合物代谢的胸腺激素所致。
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