Laboratory for Immunology and Inflammation, Instituto di Ricovero e Cura a Carattere Scientifico-Istituto Clinico Humanitas, Rozzano, Italy.
Nat Immunol. 2010 Apr;11(4):328-34. doi: 10.1038/ni.1854. Epub 2010 Mar 7.
Pentraxins are a superfamily of conserved proteins involved in the acute-phase response and innate immunity. Pentraxin 3 (PTX3), a prototypical member of the long pentraxin subfamily, is a key component of the humoral arm of innate immunity that is essential for resistance to certain pathogens. A regulatory role for pentraxins in inflammation has long been recognized, but the underlying mechanisms remain unclear. Here we report that PTX3 bound P-selectin and attenuated neutrophil recruitment at sites of inflammation. PTX3 released from activated leukocytes functioned locally to dampen neutrophil recruitment and regulate inflammation. Antibodies have glycosylation-dependent regulatory effect on inflammation. Therefore, PTX3, which is an essential component of humoral innate immunity, and immunoglobulins share functional outputs, including complement activation, opsonization and, as shown here, glycosylation-dependent regulation of inflammation.
血清淀粉样蛋白相关蛋白家族是参与急性期反应和固有免疫的保守蛋白超家族。五聚素 3（PTX3）是长五聚素亚家族的典型成员，是先天免疫体液臂的关键组成部分，对于抵抗某些病原体至关重要。长期以来，人们一直认为五聚素在炎症中具有调节作用，但潜在机制尚不清楚。在这里，我们报告 PTX3 结合 P 选择素并减弱炎症部位的中性粒细胞募集。从活化的白细胞中释放的 PTX3 在局部发挥作用，以抑制中性粒细胞募集并调节炎症。抗体对炎症具有糖基化依赖性的调节作用。因此，PTX3 是体液先天免疫的重要组成部分，与免疫球蛋白具有共同的功能输出，包括补体激活、调理作用，以及如本文所示，糖基化依赖性炎症调节。
