Ngure Peter Kamau, Ng'ang'a Zipporah, Ingonga Johnstone, Rukunga Geoffrey, Tonui Willy Kiprotich
Daystar University, Science department, 00100, Nairobi.
Afr J Tradit Complement Altern Med. 2009 Mar 7;6(2):207-12. doi: 10.4314/ajtcam.v6i2.57093.
The antileishmanial activity of extracts of Warburgia ugandensis Spraque (Canellaceae), a known traditional therapy in Kenya was evaluated in vivo. Treatment of infected BALB/c mice with W. ugandensis extracts orally resulted in a reduction of the size of lesions compared to the untreated control. The lesion sizes differed significantly for the four extracts (p=0.039) compared to the untreated control. For mice treated by intraperitoneal injection, the lesion sizes increased initially for the hexane, dichloromethane and ethyl acetate extracts and healed by day 42. The lesion sizes for mice treated with methanol increased steadily from 2.47mm to 3.57mm. The parasitic burden was significantly higher (p<0.001) in mice treated with methanol extracts and PBS compared to those treated with hexane, dichloromethane and ethyl acetate. This study demonstrated the antileishmanial potential of extracts of W. ugandensis.
乌干达沃伯格樟（樟科）提取物的抗利什曼原虫活性在肯尼亚是一种已知的传统疗法，本研究对其进行了体内评估。与未治疗的对照组相比，用乌干达沃伯格樟提取物口服治疗感染的BALB/c小鼠，可使病变大小减小。与未治疗的对照组相比，四种提取物的病变大小差异显著（p = 0.039）。对于通过腹腔注射治疗的小鼠，己烷、二氯甲烷和乙酸乙酯提取物的病变大小最初增加，到第42天愈合。用甲醇治疗的小鼠的病变大小从2.47mm稳步增加到3.57mm。与用己烷、二氯甲烷和乙酸乙酯治疗的小鼠相比，用甲醇提取物和PBS治疗的小鼠的寄生虫负荷显著更高（p<0.001）。本研究证明了乌干达沃伯格樟提取物的抗利什曼原虫潜力。
