Children's Nutritional Research Center, Childrens Hospital of Chongqing Medical University, Chongqing, P R China.
Int J Vitam Nutr Res. 2009 Jul;79(4):238-49. doi: 10.1024/0300-9831.79.4.238.
Information about the effect of antioxidant vitamins nutrition during pregnancy on offsprings intellectual development is extremely limited.
To investigate the correlation of antioxidant vitamins (Vitamin A, E and C) at delivery and the neurodevelopment of early childhood.
A total of 158 paired maternal-neonatal subjects were recruited. The serum concentrations of vitamin A, E and C in maternal and cord blood after delivery were determined and intellectual development was evaluated by Gesell Development Schedule (GDS) at two years old.
After adjusting for potential confounders, vitamin A placental transport ratio (VA-PTR) was positively associated with motor area development quotients (DQ) and average DQ(p<0.01). Cord VA level was positively related with language area and social area DQ (p<0.05). Nevertheless, there was no significant association between cord VE, VC levels, VE PTR or VC PTR and GDS. The adaptive area and average DQ in high cord VA group was higher than those in low VA group (p<0.05). Cord VA level and VA-PTR were positively associated with birth head circumference and birth weight, respectively.
Our data suggested that adequate vitamin A at delivery had beneficial influence on neonatal birth outcomes and children's neurodevelopment in later childhood.
关于怀孕期间抗氧化维生素营养对后代智力发育影响的信息极为有限。
研究分娩时的抗氧化维生素（维生素 A、E 和 C）与儿童早期神经发育的相关性。
共招募了 158 对母婴配对样本。产后测定母血和脐血中维生素 A、E 和 C 的浓度，并在 2 岁时使用 Gesell 发育量表（GDS）评估智力发育情况。
在调整了潜在混杂因素后，维生素 A 胎盘转运率（VA-PTR）与运动区发育商数（DQ）和平均 DQ 呈正相关（p<0.01）。脐血 VA 水平与语言区和社会区 DQ 呈正相关（p<0.05）。然而，脐带 VE、VC 水平、VE-PTR 或 VC-PTR 与 GDS 之间没有显著相关性。高脐 VA 组的适应区和平均 DQ 高于低 VA 组（p<0.05）。脐 VA 水平和 VA-PTR 分别与出生头围和出生体重呈正相关。
我们的数据表明，分娩时摄入足够的维生素 A 对新生儿的出生结局和儿童后期的神经发育有有益的影响。
