Yan Qingqing, Zhu Qingwen, Jiang Chen, Zhang Lingli, Xu Xiaojing
Department of Prenatal Screening and Diagnosis Center, Affiliated Maternity and Child Health Care Hospital of Nantong University, Nantong, Jiangsu, China.
Center of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
Front Pediatr. 2024 Oct 21;12:1315115. doi: 10.3389/fped.2024.1315115. eCollection 2024.
Retardation among children is a persistent global health concern. Vitamin deficiency in childhood may contribute to growth retardation; however, its causal effects are not fully understood.
Here, we aimed to explore the prediction values of fat-soluble vitamin levels on GR in children aged 1-6 years.
614 children aged from 1 to 6 years at Nantong Maternal and Child Care Health Hospital between January 2021 and December 2022 in this retrospective observational study participated in the assessment of developmental status and blood detection of vitamin from peripheral blood (PB). The relationship between vitamin levels and GR was analyzed by Multivariable logistic regression analysis.
Developmental assessment results showed that 132 cases from 614 with growth retardation (21.50%). Statistical analysis showed children with GR were more likely to be males (59.45% vs. 40.55%, = 0.191). The age of children with GR was significantly higher than those without GR ( < 0.01). Importantly, the levels of various fat-soluble vitamins in GR individuals were significantly lower than those in normal individuals. ROC analysis showed that vitamin E, vitamin A and 25(OH) D were less effective in predicting GR model (AUC: 0.87, 0.74, and 0.65,). However, the combination of vitamin E, vitamin A and 25(OH)D with age was effective in predicting GR. (AUC: 0.84, 0.77, 0.75).
The combination of 25(OH)D3, Vitamin E, Vitamin A with age may have good predictive performance for children GR aged 1-6 years.
儿童发育迟缓是一个长期存在的全球健康问题。儿童期维生素缺乏可能导致生长发育迟缓；然而，其因果关系尚未完全明确。
本研究旨在探讨1-6岁儿童脂溶性维生素水平对生长发育迟缓（GR）的预测价值。
在这项回顾性观察研究中，选取了2021年1月至2022年12月期间在南通市妇幼保健院就诊的614例1-6岁儿童，参与发育状况评估和外周血维生素检测。采用多变量逻辑回归分析维生素水平与GR之间的关系。
发育评估结果显示，614例中有132例生长发育迟缓（21.50%）。统计分析显示，GR儿童更可能为男性（59.45%对40.55%，P=0.191）。GR儿童的年龄显著高于非GR儿童（P<0.01）。重要的是，GR儿童各种脂溶性维生素水平显著低于正常儿童。受试者工作特征曲线（ROC）分析显示，维生素E、维生素A和25(OH)D对GR模型的预测效果较差（曲线下面积[AUC]：0.87、0.74和0.65）。然而，维生素E、维生素A和25(OH)D与年龄的联合对GR具有预测作用（AUC：0.84、0.77、0.75）。
25(OH)D3、维生素E、维生素A与年龄的联合对1-6岁儿童GR可能具有良好的预测性能。
