Sokolova O O, Shtark M B, Lisachev P D
Usp Fiziol Nauk. 2010 Jan-Mar;41(1):26-44.
Neuronal plasticity--a fundamental feature of brain--provides adequate interactions with dynamic environment. One of the most deeply investigated forms of the neuronal plasticity is a long-term potentiation (LTP)--a phenomenon underlying learning and memory. Signal paths activated during LTP converge into the nuclear of the neuron, giving rise to launch of the molecular-genetic programs, which mediate structural and functional remodeling of synapses. In the review data concerning involvement of multilevel gene expression into plastic change under neuronal activation are summarized.
神经元可塑性——大脑的一个基本特征——能与动态环境进行充分互动。神经元可塑性最深入研究的形式之一是长时程增强(LTP)——一种学习和记忆的基础现象。LTP过程中激活的信号通路汇聚到神经元细胞核,引发分子遗传程序的启动,这些程序介导突触的结构和功能重塑。在这篇综述中,总结了有关多级基因表达参与神经元激活下可塑性变化的数据。