University of Toronto, Department of Medical Biophysics, Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Ontario, Canada.
J Biomed Opt. 2010 Jan-Feb;15(1):011103. doi: 10.1117/1.3292007.
We demonstrate the potential of a forward-looking Doppler optical coherence tomography (OCT) probe for color flow imaging in several commonly seen narrowed artery morphologies. As a proof of concept, we present imaging results of a surgically exposed thrombotic occlusion model that was imaged superficially to demonstrate that Doppler OCT can identify flow within the recanalization channels of a blocked artery. We present Doppler OCT images in which the flow is nearly antiparallel to the imaging direction. These images are acquired using a flexible 2.2-mm-diam catheter that used electrostatic actuation to scan up to 30 deg ahead of the distal end. Doppler OCT images of physiologically relevant flow phantoms consisting of small channels and tapered entrance geometries are demonstrated.
我们展示了一种前瞻性的多普勒光相干断层扫描（OCT）探头在几种常见的狭窄动脉形态下进行彩色血流成像的潜力。作为概念验证，我们展示了手术暴露的血栓闭塞模型的成像结果，该模型进行了表面成像，以证明多普勒 OCT 可以识别阻塞动脉的再通通道内的血流。我们展示了血流几乎与成像方向相反的多普勒 OCT 图像。这些图像是使用直径为 2.2 毫米的柔性导管采集的，该导管使用静电激励来扫描远端前方多达 30 度的范围。我们还展示了由小通道和锥形入口几何形状组成的生理相关流动体模的多普勒 OCT 图像。
