Yang Victor X D, Mao You X, Munce Nigel, Standish Beau, Kucharczyk Walter, Marcon Norman E, Wilson Brian C, Vitkin I Alex
University Health Network, Toronto, Ontario, Canada.
Opt Lett. 2005 Jul 15;30(14):1791-3. doi: 10.1364/ol.30.001791.
Doppler optical coherence tomography (OCT) can image tissue structure and blood flow at micrometer-scale resolution but has limited imaging depth. We report a novel, linear-scanning, needle-based Doppler OCT system using angle-polished gradient-index or ball-lensed fibers. A prototype system with a 19-guage (diameter of approximately 0.9 mm) echogenic needle is constructed and demonstrates in vivo imaging of bidirectional blood flow in rat leg and abdominal cavity. To our knowledge, this is the first demonstration of Doppler OCT through a needle probe in interstitial applications to visualize deeply situated microcirculation.
多普勒光学相干断层扫描（OCT）能够以微米级分辨率对组织结构和血流进行成像，但成像深度有限。我们报告了一种新型的、基于线性扫描针的多普勒OCT系统，该系统使用角度抛光的梯度折射率光纤或球透镜光纤。构建了一个带有19号（直径约0.9毫米）回声针的原型系统，并展示了在大鼠腿部和腹腔内双向血流的体内成像。据我们所知，这是首次通过针状探头在组织间应用中进行多普勒OCT成像，以可视化深部微循环。
