肝炎 delta 病毒的起源。
Origin of hepatitis delta virus.
机构信息
Fox Chase Cancer Center, PA 19111, USA.
出版信息
Future Microbiol. 2010 Mar;5(3):393-402. doi: 10.2217/fmb.10.15.
Abstract
This article addresses some of the questions relating to how hepatitis delta virus (HDV), an agent so far unique in the animal world, might have arisen. HDV was discovered in patients infected with hepatitis B virus (HBV). It generally makes HBV infections more damaging to the liver. It is a subviral satellite agent that depends upon HBV envelope proteins for its assembly and ability to infect new cells. In other aspects of replication, HDV is both independent of and very different from HBV. In addition, the small single-stranded circular RNA genome of HDV, and its mechanism of replication, demonstrate an increasing number of similarities to the viroids - a large family of helper-independent subviral agents that cause pathogenesis in plants.
摘要
本文探讨了一些与乙型肝炎病毒 (HBV) 相关的问题，该病毒是一种在动物界中独特的病原体。HDV 是在感染 HBV 的患者中发现的。它通常使 HBV 感染对肝脏的损害更大。它是一种亚病毒卫星因子，其组装和感染新细胞的能力依赖于 HBV 包膜蛋白。在复制的其他方面，HDV 既独立于 HBV，又与其有很大的不同。此外，HDV 的小单链环状 RNA 基因组及其复制机制与类病毒越来越相似——类病毒是一大类无辅助因子的亚病毒因子，它们在植物中引起发病机制。
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