一种新型的聚甲基丙烯酸甲酯亲水性黏合剂基质，旨在用于透皮贴剂制剂。

A novel polymethylmethacrylate hydrophilic adhesive matrix intended for transdermal patch formulations.

机构信息

Department of Pharmaceutical Sciences 'Pietro Pratesi', Università degli Studi di Milano, via G. Colombo, 71-20133 Milan, Italy.

出版信息

Drug Deliv. 2010 Apr;17(3):171-7. doi: 10.3109/10717541003667772.

DOI:10.3109/10717541003667772

PMID:20210561

Abstract

A novel poly(sodium methacrylate, methylmethacrylate) hydrophilic pressure sensitive adhesive (PSA) containing a large amount of water was designed. The effects of PEG400, glycerin, sorbitol, and/or NaCl on the in vitro and in vivo adhesive properties were investigated by means of a 2(4) full factorial design. The optimized formulation, containing all independent variables at the highest value, was loaded with lidocaine hydrochloride (LH). This formulation permitted to obtain a 4-fold higher LH flux through human skin with respect to the marketed products.

摘要

设计了一种新型的含有大量水的聚（甲基丙烯酸甲酯，甲基丙烯酸甲酯）亲水性压敏胶（PSA）。通过 2（4）完全因子设计研究了 PEG400、甘油、山梨糖醇和/或 NaCl 对体外和体内粘合性能的影响。含有所有自变量最高值的优化配方与盐酸利多卡因（LH）一起使用。与市售产品相比，该配方使 LH 通过人体皮肤的通量增加了 4 倍。