• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用于酮洛芬经皮给药的新型水基贴剂的开发与评价

Development and Evaluation of Novel Water-Based Drug-in-Adhesive Patches for the Transdermal Delivery of Ketoprofen.

作者信息

Arunprasert Kwanputtha, Pornpitchanarong Chaiyakarn, Rojanarata Theerasak, Ngawhirunpat Tanasait, Opanasopit Praneet, Aumklad Porawan, Patrojanasophon Prasopchai

机构信息

Pharmaceutical Development of Green Innovations Group (PDGIG), Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.

OLIC (Thailand) Limited, Bang Pa-in, Ayutthaya 13160, Thailand.

出版信息

Pharmaceutics. 2021 May 25;13(6):789. doi: 10.3390/pharmaceutics13060789.

DOI:10.3390/pharmaceutics13060789
PMID:34070540
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8228130/
Abstract

The objective of this study was to develop novel water-based drug-in-adhesive pressure-sensitive adhesives (PSAs) patches for the transdermal delivery of ketoprofen, employing poly(-vinylpyrrolidone-co-acrylic acid) copolymer (PVPAA) and poly(methyl vinyl ether-alt-maleic anhydride) (PMVEMA) as the main components. The polymers were crosslinked with tartaric acid and dihydroxyaluminium aminoacetate using various polymer ratios. Ketoprofen was incorporated into the PVPAA/PMVEMA PSAs during the patch preparation. The physicochemical properties, adhesive properties, drug content, release profile, and skin permeation of the patches were examined. Moreover, the in vivo skin irritation and skin adhesion performance in human volunteers were evaluated. The patches prepared at a weight ratio of PVPAA/PMVEMA of 1:1 presented the highest tacking strength, with desirable peeling characteristics. The ketoprofen-loaded PVPAA/PMVEMA patches exhibited superior adhesive properties, compared to the commercial patches, because the former showed an appropriate crosslinking and hydrating status with the aid of a metal coordination complex. Besides, the permeated flux of ketoprofen through the porcine skin of the ketoprofen-loaded PVPAA/PMVEMA patches (4.77 ± 1.00 µg/cm/h) was comparable to that of the commercial patch (4.33 ± 0.80 µg/cm/h). In human studies, the PVPAA/PMVEMA patches exhibited a better skin adhesion performance, compared with the commercial patches, without skin irritation. In addition, the patches were stable for 6 months. Therefore, these novel water-based PSAs may be a potential adhesive for preparing drug-in-adhesive patches.

摘要

本研究的目的是开发用于酮洛芬经皮给药的新型水基药物-胶粘剂压敏胶粘剂（PSA）贴剂，采用聚（乙烯基吡咯烷酮-共-丙烯酸）共聚物（PVPAA）和聚（甲基乙烯基醚-alt-马来酸酐）（PMVEMA）作为主要成分。使用各种聚合物比例，将聚合物与酒石酸和氨基乙酸二羟基铝交联。在贴剂制备过程中，将酮洛芬掺入PVPAA/PMVEMA PSA中。对贴剂的物理化学性质、粘附性能、药物含量、释放曲线和皮肤渗透性进行了研究。此外，还评估了人体志愿者体内的皮肤刺激性和皮肤粘附性能。以1:1的重量比制备的PVPAA/PMVEMA贴剂具有最高的粘性强度，具有理想的剥离特性。与市售贴剂相比，负载酮洛芬的PVPAA/PMVEMA贴剂表现出优异的粘附性能，因为前者在金属配位络合物的帮助下显示出适当的交联和水合状态。此外，负载酮洛芬的PVPAA/PMVEMA贴剂中酮洛芬透过猪皮的渗透通量（4.77±1.00μg/cm/h）与市售贴剂（4.33±0.80μg/cm/h）相当。在人体研究中，与市售贴剂相比，PVPAA/PMVEMA贴剂表现出更好的皮肤粘附性能，且无皮肤刺激性。此外，贴剂在6个月内保持稳定。因此，这些新型水基PSA可能是制备药物-胶粘剂贴剂的潜在胶粘剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8420/8228130/c8e688e8d1d1/pharmaceutics-13-00789-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8420/8228130/da9cd0681157/pharmaceutics-13-00789-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8420/8228130/34a7578aa603/pharmaceutics-13-00789-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8420/8228130/79fae332076a/pharmaceutics-13-00789-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8420/8228130/0e5912d41562/pharmaceutics-13-00789-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8420/8228130/eaf68f71841a/pharmaceutics-13-00789-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8420/8228130/3ec6fb8b20cb/pharmaceutics-13-00789-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8420/8228130/1f253b8ce5ef/pharmaceutics-13-00789-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8420/8228130/d15bfae37485/pharmaceutics-13-00789-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8420/8228130/c8e688e8d1d1/pharmaceutics-13-00789-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8420/8228130/da9cd0681157/pharmaceutics-13-00789-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8420/8228130/34a7578aa603/pharmaceutics-13-00789-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8420/8228130/79fae332076a/pharmaceutics-13-00789-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8420/8228130/0e5912d41562/pharmaceutics-13-00789-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8420/8228130/eaf68f71841a/pharmaceutics-13-00789-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8420/8228130/3ec6fb8b20cb/pharmaceutics-13-00789-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8420/8228130/1f253b8ce5ef/pharmaceutics-13-00789-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8420/8228130/d15bfae37485/pharmaceutics-13-00789-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8420/8228130/c8e688e8d1d1/pharmaceutics-13-00789-g009.jpg

相似文献

1
Development and Evaluation of Novel Water-Based Drug-in-Adhesive Patches for the Transdermal Delivery of Ketoprofen.用于酮洛芬经皮给药的新型水基贴剂的开发与评价
Pharmaceutics. 2021 May 25;13(6):789. doi: 10.3390/pharmaceutics13060789.
2
Mussel-inspired poly(hydroxyethyl acrylate-co-itaconic acid)-catechol/hyaluronic acid drug-in-adhesive patches for transdermal delivery of ketoprofen.贻贝启发的聚（丙烯酸羟乙酯-衣康酸）-儿茶酚/透明质酸药物黏附贴剂用于酮洛芬的透皮给药
Int J Pharm. 2022 Dec 15;629:122362. doi: 10.1016/j.ijpharm.2022.122362. Epub 2022 Nov 13.
3
Bioinspired ketoprofen-incorporated polyvinylpyrrolidone/polyallylamine/ polydopamine hydrophilic pressure-sensitive adhesives patches with improved adhesive performance for transdermal drug delivery.受生物启发的含酮洛芬的聚乙烯吡咯烷酮/聚烯丙胺/聚多巴胺亲水性压敏胶粘剂贴片，具有改善的经皮给药粘附性能。
Eur J Pharm Biopharm. 2022 Dec;181:207-217. doi: 10.1016/j.ejpb.2022.11.007. Epub 2022 Nov 15.
4
Design and evaluation of a drug-in-adhesive patch for the transdermal delivery of ketoprofen.用于酮洛芬经皮递送的贴剂中含药贴剂的设计与评价
Drug Deliv Transl Res. 2025 May;15(5):1685-1692. doi: 10.1007/s13346-024-01703-w. Epub 2024 Sep 6.
5
A strong, silk protein-inspired tissue adhesive with an enhanced drug release mechanism for transdermal drug delivery.一种具有增强药物释放机制的强力、仿丝蛋白组织粘合剂，用于经皮药物传递。
Acta Biomater. 2024 Jun;181:133-145. doi: 10.1016/j.actbio.2024.04.024. Epub 2024 Apr 18.
6
Design of pressure-sensitive adhesive suitable for the preparation of transdermal patches by hot-melt printing.设计适用于热熔印刷制备透皮贴剂的压敏胶。
Int J Pharm. 2020 Aug 30;586:119607. doi: 10.1016/j.ijpharm.2020.119607. Epub 2020 Jul 8.
7
Evaluation of the Structural Modification of Ibuprofen on the Penetration Release of Ibuprofen from a Drug-in-Adhesive Matrix Type Transdermal Patch.评价布洛芬结构修饰对药物粘附基质型透皮贴剂中布洛芬渗透释放的影响。
Int J Mol Sci. 2022 Jul 13;23(14):7752. doi: 10.3390/ijms23147752.
8
Formulation and evaluation of 4-benzylpiperidine drug-in-adhesive matrix type transdermal patch.4-苄基哌啶药物-黏附基质型透皮贴剂的制备与评价。
Int J Pharm. 2018 Oct 25;550(1-2):71-78. doi: 10.1016/j.ijpharm.2018.08.033. Epub 2018 Aug 17.
9
Tuning the rheological properties of an ammonium methacrylate copolymer for the design of adhesives suitable for transdermal patches.调整甲基丙烯酰胺铵共聚物的流变性能，以设计适合透皮贴剂的粘合剂。
Eur J Pharm Sci. 2018 Jan 1;111:238-246. doi: 10.1016/j.ejps.2017.10.006. Epub 2017 Oct 5.
10
Enhancing Transdermal Delivery: Investigating the Impact of Permeation Promoters on Ibuprofen Release and Penetration from Medical Patches-In Vitro Research.增强透皮传递：研究促渗剂对贴剂中布洛芬释放和渗透的影响——体外研究。
Int J Mol Sci. 2023 Oct 26;24(21):15632. doi: 10.3390/ijms242115632.

引用本文的文献

1
Establishment and Validation of a Transdermal Drug Delivery System for the Anti-Depressant Drug Citalopram Hydrobromide.建立并验证抗抑郁药氢溴酸西酞普兰的透皮给药系统。
Molecules. 2024 Feb 7;29(4):767. doi: 10.3390/molecules29040767.
2
A Fast HPLC/UV Method for Determination of Ketoprofen in Cellular Media.一种快速 HPLC/UV 法测定细胞培养基中酮洛芬的含量。
ChemistryOpen. 2024 Mar;13(3):e202300147. doi: 10.1002/open.202300147. Epub 2023 Nov 13.
3
Design, Development, and Evaluation of Treprostinil Embedded Adhesive Transdermal Patch.

本文引用的文献

1
Hydrogel-Based Active Substance Release Systems for Cosmetology and Dermatology Application: A Review.用于美容和皮肤科应用的水凝胶基活性物质释放系统：综述
Pharmaceutics. 2020 Apr 26;12(5):396. doi: 10.3390/pharmaceutics12050396.
2
Non-invasive drug delivery technology: development and current status of transdermal drug delivery devices, techniques and biomedical applications.非侵入性给药技术：透皮给药装置、技术及生物医学应用的发展与现状
Biomed Tech (Berl). 2020 May 26;65(3):243-272. doi: 10.1515/bmt-2019-0019.
3
Synthesis of novel N-vinylpyrrolidone/acrylic acid nanoparticles as drug delivery carriers of cisplatin to cancer cells.
曲前列尼尔嵌入式黏附透皮贴剂的设计、开发与评价
Pharmaceutics. 2023 Apr 12;15(4):1226. doi: 10.3390/pharmaceutics15041226.
4
Losartan Potassium and Verapamil Hydrochloride Compound Transdermal Drug Delivery System: Formulation and Characterization.氯沙坦钾-盐酸维拉帕米复方经皮给药系统的制备与评价。
Int J Mol Sci. 2022 Oct 27;23(21):13051. doi: 10.3390/ijms232113051.
5
Transdermal delivery of inflammatory factors regulated drugs for rheumatoid arthritis.经皮传递调控炎症因子的药物治疗类风湿关节炎。
Drug Deliv. 2022 Dec;29(1):1934-1950. doi: 10.1080/10717544.2022.2089295.
6
The Effect of Type-I Photoinitiators on the Kinetics of the UV-Induced Cotelomerization Process of Acrylate Monomers and Properties of Obtained Pressure-Sensitive Adhesives.I型光引发剂对丙烯酸酯单体紫外诱导共调聚反应动力学及所得压敏胶性能的影响
Materials (Basel). 2021 Aug 13;14(16):4563. doi: 10.3390/ma14164563.
合成新型 N-乙烯基吡咯烷酮/丙烯酸纳米粒子作为顺铂向癌细胞的药物输送载体。
Colloids Surf B Biointerfaces. 2020 Jan 1;185:110566. doi: 10.1016/j.colsurfb.2019.110566. Epub 2019 Oct 7.
4
Development of Sponge Microspicule Cream as a Transdermal Delivery System for Protein and Growth Factors from Deer Antler Velvet Extract.海绵微针乳膏作为从鹿茸提取物中传递蛋白质和生长因子的透皮给药系统的研制。
Biol Pharm Bull. 2019;42(7):1207-1215. doi: 10.1248/bpb.b19-00158.
5
Bioadhesive and biodissolvable hydrogels consisting of water-swellable poly(acrylic acid)/poly(vinylpyrrolidone) complexes.由可水溶胀的聚（丙烯酸）/聚（聚乙烯吡咯烷酮）复合物组成的生物粘附性和生物可降解水凝胶。
J Biomed Mater Res B Appl Biomater. 2020 Feb;108(2):503-512. doi: 10.1002/jbm.b.34407. Epub 2019 May 8.
6
Synthesis and Biomedical Applications of Self-healing Hydrogels.自愈水凝胶的合成与生物医学应用
Front Chem. 2018 Oct 2;6:449. doi: 10.3389/fchem.2018.00449. eCollection 2018.
7
Synthesis and characterization of hyaluronic acid hydrogels crosslinked using a solvent-free process for potential biomedical applications.采用无溶剂法交联透明质酸水凝胶的合成与表征及其在潜在生物医学中的应用。
Carbohydr Polym. 2018 Feb 1;181:1194-1205. doi: 10.1016/j.carbpol.2017.12.015. Epub 2017 Dec 7.
8
Transdermal Adhesive Patches Loaded with Ketoprofen Evaluated by Dynamic Detection of Percutaneous Absorption.通过动态检测经皮吸收评估载有酮洛芬的透皮贴剂
AAPS PharmSciTech. 2017 Aug;18(6):2141-2148. doi: 10.1208/s12249-016-0695-8. Epub 2016 Dec 29.
9
Role of pressure-sensitive adhesives in transdermal drug delivery systems.压敏胶在透皮给药系统中的作用。
Ther Deliv. 2016;7(1):33-48. doi: 10.4155/tde.15.87.
10
Current pharmaceutical design on adhesive based transdermal drug delivery systems.基于粘合剂的透皮给药系统的当前药物设计。
Curr Pharm Des. 2015;21(20):2771-83. doi: 10.2174/1381612821666150428130215.