Bulbul Ali, Karadag Ahmet, Köklü Esad, Pamuk Utku, Sarici Serdar Umit
Division of Neonatology, Department of Pediatrics, Gulhane Military Medical Academy, Ankara, Turkey.
J Matern Fetal Neonatal Med. 2010 Oct;23(10):1257-9. doi: 10.3109/14767051003653260.
Hepatitis B immunoglobulin (HBIG) is administered for the passive immunisation of all infants born to HBsAg-positive mothers within 12 h of birth. Adverse effects of HBIG are very rare. In this study, we report a newborn (a female, 33 weeks' gestation and 2030 g birth weight) developing anaphylaxis after HBIG administration. The mother was a Hepatitis B virus (HBV) carrier. Hypotension and erythematous rash developed 7 min after HBIG administration. Reporting the first anaphylaxis case in newborns due to HBIG in literature, we suggest the condition be taken into account, and requisite precautions should be taken against this probable complication in the newborn.
乙肝免疫球蛋白（HBIG）用于对所有HBsAg阳性母亲所生婴儿在出生后12小时内进行被动免疫。HBIG的不良反应非常罕见。在本研究中，我们报告了一名新生儿（女性，孕33周，出生体重2030克）在接种HBIG后发生过敏反应。母亲为乙肝病毒（HBV）携带者。接种HBIG后7分钟出现低血压和红斑疹。鉴于本文献报道了首例新生儿因HBIG发生过敏反应的病例，我们建议应考虑到这种情况，并针对新生儿这一可能的并发症采取必要的预防措施。
