Carpenter Susan, Dobbs Drena
Department of Animal Science, Iowa State University, Ames, Iowa 50011-3260, USA.
Curr HIV Res. 2010 Jan;8(1):87-93. doi: 10.2174/157016210790416424.
Equine infectious anemia virus (EIAV) is one of the most divergent members of the lentivirus subfamily of retroviruses and is considered a useful comparative model for molecular studies of lentivirus replication. The Rev protein of EIAV is functionally homologous with other lentiviral Revs and facilitates export of incompletely spliced viral mRNAs through a Crm1-dependent pathway. The trans- and cis-acting elements that mediate EIAV Rev function are similar to, but distinct from, the well-characterized elements in human immunodeficiency virus (HIV-1), the prototypical Rev protein. In addition, the EIAV rev sequence is highly variable in vivo, and changes in Rev phenotype correlate with changes in clinical stages of EIAV infection. This review summarizes the molecular biology of EIAV Rev-RRE interactions and the consequences of Rev variation in vivo. A comparative perspective of Rev activity may enhance understanding of an essential lentiviral protein and stimulate new strategies for treatment and prevention of lentivirus infections in vivo.
马传染性贫血病毒（EIAV）是逆转录病毒慢病毒亚科中差异最大的成员之一，被认为是慢病毒复制分子研究的有用比较模型。EIAV的Rev蛋白在功能上与其他慢病毒Rev蛋白同源，并通过依赖Crm1的途径促进不完全剪接的病毒mRNA的输出。介导EIAV Rev功能的反式和顺式作用元件与人类免疫缺陷病毒（HIV-1）中典型的Rev蛋白中特征明确的元件相似，但又有所不同。此外，EIAV rev序列在体内高度可变，Rev表型的变化与EIAV感染临床阶段的变化相关。本综述总结了EIAV Rev-RRE相互作用的分子生物学以及Rev在体内变异的后果。对Rev活性的比较观点可能会增强对一种重要慢病毒蛋白的理解，并激发体内慢病毒感染治疗和预防的新策略。
