MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB0 2QH, UK.
Cell. 2010 Mar 5;140(5):601-5. doi: 10.1016/j.cell.2010.02.017.
Recent evidence suggests that the Ca(2+)-sensors synaptotagmin-1 and Doc2b deform synaptic membranes during synaptic vesicle exocytosis. We discuss how local curvature generated by these and other proteins may stimulate membrane fusion and discuss the potential implications of these findings for other cellular fusion events.
最近的证据表明,Ca(2+)-感受器突触融合蛋白 1 和 Doc2b 在突触小泡胞吐过程中使突触膜变形。我们讨论了这些蛋白和其他蛋白产生的局部曲率如何刺激膜融合,并讨论了这些发现对其他细胞融合事件的潜在影响。