膜蛋白与膜曲率：相互作用及疾病治疗展望。
Membrane Proteins and Membrane Curvature: Mutual Interactions and a Perspective on Disease Treatments.
机构信息
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory & Center for Molecular Imaging and Translational Medicine, School of Public Health, Shenzhen Research Institute of Xiamen University, Xiamen University, Xiamen 361102, China.
出版信息
Biomolecules. 2023 Dec 11;13(12):1772. doi: 10.3390/biom13121772.
The pathogenesis of various diseases often involves an intricate interplay between membrane proteins and membrane curvature. Understanding the underlying mechanisms of this interaction could offer novel perspectives on disease treatment. In this review, we provide an introduction to membrane curvature and its association with membrane proteins. Furthermore, we delve into the impact and potential implications of this interaction in the context of disease treatment. Lastly, we discuss the prospects and challenges associated with harnessing these interactions for effective disease management, aiming to provide fresh insights into therapeutic strategies.
各种疾病的发病机制通常涉及膜蛋白和膜曲率之间的复杂相互作用。了解这种相互作用的潜在机制可以为疾病治疗提供新的视角。在这篇综述中，我们介绍了膜曲率及其与膜蛋白的关系。此外，我们深入探讨了这种相互作用在疾病治疗中的影响和潜在意义。最后，我们讨论了利用这些相互作用进行有效疾病管理的前景和挑战，旨在为治疗策略提供新的见解。
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