Jones D Y, Miller K W, Koonsvitsky B P, Ebert M L, Lin P Y, Jones M B, DeLuca H F
Procter & Gamble Company, Cincinnati, OH 45224.
Am J Clin Nutr. 1991 May;53(5):1281-7. doi: 10.1093/ajcn/53.5.1281.
The effect of olestra on vitamin D status was assessed in a 6-wk, double-blind, placebo-controlled study involving 202 free-living adults. Subjects consumed a total of 20 g/d of olestra or triglycerides in cookies eaten at each meal. A 20-micrograms ergocalciferol capsule was taken with each morning meal. Serum 25-hydroxyergocalciferol (25-OHD2) concentrations rose from approximately 5.7 to 39.0 and 31.7 nmol/L in the placebo and olestra groups, respectively, at week 6. At week 6, 25-OHD2 contributed 46-54% to total serum 25-OHD concentration compared with 11% at baseline. The 19% decrease in serum 25-OHD2 concentrations produced by olestra in this study is equivalent to a decrease of approximately 1.2 nmol/L under nonsupplemented dietary conditions. Ingesting 20 g olestra/d in the diet is thus not expected to affect vitamin D nutritional status.
在一项为期6周的双盲、安慰剂对照研究中，对202名自由生活的成年人进行了奥利司他对维生素D状态影响的评估。受试者每餐食用的饼干中总共含有20克/天的奥利司他或甘油三酯。每天早餐时服用一粒20微克的麦角钙化醇胶囊。在第6周时，安慰剂组和奥利司他组的血清25-羟麦角钙化醇（25-OHD2）浓度分别从约5.7纳摩尔/升升至39.0纳摩尔/升和31.7纳摩尔/升。在第6周时，与基线时的11%相比，25-OHD2占总血清25-OHD浓度的46%-54%。在本研究中，奥利司他使血清25-OHD2浓度降低了19%，这相当于在非补充饮食条件下约降低1.2纳摩尔/升。因此，预计饮食中每天摄入20克奥利司他不会影响维生素D的营养状况。
