Jones D Y, Koonsvitsky B P, Ebert M L, Jones M B, Lin P Y, Will B H, Suttie J W
Procter & Gamble Company, Cincinnati, OH 45224.
Am J Clin Nutr. 1991 Apr;53(4):943-6. doi: 10.1093/ajcn/53.4.943.
The potential for 20 g olestra/d to affect vitamin K status was assessed in a 6-wk study involving 202 free-living subjects. Functional prothrombin [Simplastin (S)-Ecarin (E) assay] concentrations and classical clotting times were unaffected by olestra. Initial S:E values were 0.80 and 0.79 for the olestra and placebo groups, respectively, compared with a value of 0.92 for normal reference plasma. At week 6 the value was 0.81 for both groups. Mean phylloquinone serum concentrations, expressed as differences from baseline, were not significantly different between groups. Weekly food diaries indicated that the average phylloquinone intake of the subjects was low, approximately 60 micrograms/d. Sensitive measures of vitamin K status were unaffected in a population where any significant decrease in phylloquinone bioavailability should have been reflected in those measures, indicating that 20 g olestra/d in the diet did not affect vitamin K status.
在一项为期6周、涉及202名自由生活受试者的研究中，评估了每天摄入20克奥利司他对维生素K状态的影响。功能性凝血酶原[简易凝血酶原时间（S）-蛇毒凝血酶（E）检测法]浓度和传统凝血时间不受奥利司他影响。奥利司他组和安慰剂组的初始S:E值分别为0.80和0.79，而正常参考血浆的值为0.92。在第6周时，两组的值均为0.81。以与基线的差值表示的平均叶绿醌血清浓度在两组之间无显著差异。每周的食物日记表明，受试者的平均叶绿醌摄入量较低，约为每日60微克。在一个人群中，维生素K状态的敏感指标未受影响，在该人群中，叶绿醌生物利用度的任何显著降低都应在这些指标中得到体现，这表明饮食中每天摄入20克奥利司他不会影响维生素K状态。
