Longnecker M P, Taylor P R, Levander O A, Howe M, Veillon C, McAdam P A, Patterson K Y, Holden J M, Stampfer M J, Morris J S
Department of Epidemiology, UCLA School of Public Health, CA 90024.
Am J Clin Nutr. 1991 May;53(5):1288-94. doi: 10.1093/ajcn/53.5.1288.
To determine whether high dietary selenium intake was associated with adverse effects, selenium in diet, blood, and toenails was studied in relation to human health in adults residing in western South Dakota and eastern Wyoming. Over a 2-y period 142 subjects were recruited from households selected at random and from ranches where unusually high selenium intakes were suspected. Subjects completed health questionnaires, underwent physical examinations, provided blood samples for clinical assessment, and provided blood, urine, toenails, and duplicate-plate food collections for selenium analysis. About half of the 142 free-living subjects had selenium intakes greater than 2.54 mumol/d (200 micrograms/d) (range 0.86-9.20 mumol/d, or 68-724 micrograms/d). Physical findings characteristic of selenium toxicity were not present nor were clinically significant changes in laboratory tests or frequency of symptoms related to selenium in the blood, toenails, or diet. We found no evidence of toxicity from selenium in subjects whose intake was as high as 9.20 mumol/d (724 micrograms/d).
为了确定高膳食硒摄入量是否与不良反应相关，我们对南达科他州西部和怀俄明州东部成年人的饮食、血液和趾甲中的硒与人体健康的关系进行了研究。在两年时间里，我们从随机选择的家庭以及怀疑硒摄入量异常高的牧场招募了142名受试者。受试者完成了健康问卷，接受了体格检查，提供了用于临床评估的血液样本，并提供了血液、尿液、趾甲以及用于硒分析的双份餐盘食物样本。在这142名自由生活的受试者中，约一半人的硒摄入量大于2.54 μmol/d（200微克/d）（范围为0.86 - 9.20 μmol/d，即68 - 724微克/d）。没有出现硒中毒的体征，实验室检查也没有临床显著变化，血液、趾甲或饮食中与硒相关的症状频率也没有变化。我们没有发现摄入量高达9.20 μmol/d（724微克/d）的受试者有硒中毒的证据。
