Swanson C A, Longnecker M P, Veillon C, Howe M, Levander O A, Taylor P R, McAdam P A, Brown C C, Stampfer M J, Willett W C
National Cancer Institute, NIH, Bethesda, MD 20892.
Am J Clin Nutr. 1990 Nov;52(5):858-62. doi: 10.1093/ajcn/52.5.858.
Duplicate meals, serum, whole blood, and toenails were collected every 3 mo for 1 y from a group of 44 free-living adults residing in high-selenium areas of South Dakota and Wyoming to assess the relation of selenium intake to indices of selenium status. The average selenium values for the group were as follows: dietary intake, 174 +/- 91 micrograms/d (mean +/- SD), 2.33 +/- 1.08 micrograms/kg body wt; serum, 2.10 +/- 0.38 mumol/L; whole blood, 3.22 +/- 0.79 mumol/L; and toenails, 15.2 +/- 3.0 nmol/g. Selenium intake (micrograms/kg body wt) was strongly correlated (all values, P less than 0.01) with selenium concentration of serum (r = 0.63), whole blood (r = 0.62), and toenails (r = 0.59). Men and women had similar mean values of serum, whole blood, and toenail selenium despite higher selenium intakes in men. Smokers had lower tissue selenium concentrations than did nonsmokers due, at least in part, to lower selenium intake. Age was not associated with tissue selenium content. Of the variables examined selenium intake was clearly the strongest predictor of tissue selenium concentration.
从居住在南达科他州和怀俄明州高硒地区的44名自由生活的成年人中，每3个月收集一次重复的膳食、血清、全血和脚趾甲样本，共收集1年，以评估硒摄入量与硒状态指标之间的关系。该组的平均硒值如下：膳食摄入量为174±91微克/天（均值±标准差），2.33±1.08微克/千克体重；血清为2.10±0.38微摩尔/升；全血为3.22±0.79微摩尔/升；脚趾甲为15.2±3.0纳摩尔/克。硒摄入量（微克/千克体重）与血清（r = 0.63）、全血（r = 0.62）和脚趾甲（r = 0.59）中的硒浓度密切相关（所有值，P < 0.01）。尽管男性的硒摄入量较高，但男性和女性的血清、全血和脚趾甲硒的平均值相似。吸烟者的组织硒浓度低于不吸烟者，至少部分原因是硒摄入量较低。年龄与组织硒含量无关。在所检查的变量中，硒摄入量显然是组织硒浓度的最强预测因子。
