Department of Hematology, Kuwait Cancer Control Center, Shuwalkh, Kuwait.
Leuk Res. 2010 Dec;34(12):1617-21. doi: 10.1016/j.leukres.2010.02.011. Epub 2010 Mar 7.
Adult T-cell leukemia/lymphoma is a distinct clinical entity characterized by a clonal proliferation of malignant T-lymphocytes. The etiologic agent of the disease is a Human T-cell lymphotropic virus type I. It occurs almost exclusively in areas where the virus is endemic; however the disease develops only in the minority of patients who are virus carriers. Karyotyping findings and their correlation with clinical features are still limited in T-cell malignancies, complicated by clinical heterogeneity and a plethora of secondary abnormalities. This study describes detailed chromosomal and fluorescence in situ hybridization results observed in a patient with adult T-cell leukemia/lymphoma and correlates them with clinical characteristics.
成人 T 细胞白血病/淋巴瘤是一种以恶性 T 淋巴细胞克隆性增殖为特征的独特临床实体。该病的病原体是人 T 细胞嗜淋巴细胞病毒 I 型。它几乎只发生在病毒流行的地区；然而，只有少数病毒携带者会患上这种疾病。细胞遗传学发现及其与临床特征的相关性在 T 细胞恶性肿瘤中仍然有限，这是由于临床异质性和大量继发性异常所导致的。本研究描述了一例成人 T 细胞白血病/淋巴瘤患者的详细染色体和荧光原位杂交结果，并将其与临床特征进行了相关性分析。
