Department of Developmental Biology, Sloan-Kettering Institute, 1275 York Ave, Box 252, New York, NY 10065, USA.
Semin Cell Dev Biol. 2010 Sep;21(7):745-53. doi: 10.1016/j.semcdb.2010.03.001. Epub 2010 Mar 6.
microRNAs (miRNAs) comprise an extensive class of post-transcriptional regulatory molecules in higher eukaryotes. Intensive research in Drosophila has revealed that miRNAs control myriad developmental and physiological processes. Interestingly, several of the best-studied miRNAs impact multiple biological processes, often by regulating distinct key target genes in each setting. Here we discuss the roles of some of these pleiotropic miRNAs, and their implications for studying and interpreting the roles of miRNAs in gene regulatory networks.
microRNAs (miRNAs) 是高等真核生物中一类广泛存在的转录后调控分子。在果蝇中的深入研究表明,miRNAs 控制着众多的发育和生理过程。有趣的是,一些研究最深入的 miRNAs 影响多种生物学过程,通常通过在每种情况下调节不同的关键靶基因来实现。在这里,我们讨论了其中一些多效性 miRNAs 的作用,以及它们对研究和解释 miRNAs 在基因调控网络中的作用的意义。