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微小RNA在发育过程中的生物学作用

The Biological Roles of microRNAs in Development.

作者信息

Jang Daegyu, Kim Chae Jeong, Shin Bo Hyun, Lim Do-Hwan

机构信息

School of Systems Biomedical Science, Soongsil University, Seoul 06978, Republic of Korea.

出版信息

Insects. 2024 Jun 30;15(7):491. doi: 10.3390/insects15070491.

Abstract

is a well-established insect model system for studying various physiological phenomena and developmental processes, with a focus on gene regulation. development is controlled by programmed regulatory mechanisms specific to individual tissues. When key developmental processes are shared among various insects, the associated regulatory networks are believed to be conserved across insects. Thus, studies of developmental regulation in have substantially contributed to our understanding of insect development. Over the past two decades, studies on microRNAs (miRNAs) in have revealed their crucial regulatory roles in various developmental processes. This review focuses on the biological roles of miRNAs in specific tissues and processes associated with development. Additionally, as a future direction, we discuss sequencing technologies that can analyze the interactions between miRNAs and their target genes, with the aim of enhancing miRNA studies in development.

摘要

是一个成熟的昆虫模型系统,用于研究各种生理现象和发育过程,重点是基因调控。发育由特定于各个组织的程序性调控机制控制。当关键发育过程在各种昆虫中共享时,相关的调控网络被认为在昆虫中是保守的。因此,对[昆虫名称]发育调控的研究极大地促进了我们对昆虫发育的理解。在过去二十年中,对[昆虫名称]中微小RNA(miRNA)的研究揭示了它们在各种发育过程中的关键调控作用。本综述重点关注miRNA在与[昆虫名称]发育相关的特定组织和过程中的生物学作用。此外,作为未来的方向,我们讨论了能够分析miRNA与其靶基因之间相互作用的测序技术,旨在加强对[昆虫名称]发育中miRNA的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71d1/11277110/6a0d321c9bcc/insects-15-00491-g001.jpg

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