Department of Pathology, Shizuoka City Shimizu Hospital, Shizuoka, Japan.
Spinal Cord. 2010 Oct;48(10):776-8. doi: 10.1038/sc.2010.18. Epub 2010 Mar 9.
Autopsy cases of isolated spinal neurosarcoidosis are extremely rare or none.
To report an autopsy case of isolated spinal neurosarcoidosis without the involvement of other organs.
A few reports of isolated spinal neurosarcoidosis are present, but no autopsy cases of isolated spinal neurosarcoidosis are present in the English literature.
Japan.
An autopsy case of isolated spinal neurosarcoidosis was examined pathologically.
A 54-year-old woman was admitted to our hospital because of leg numbness and muscle weakness. Imaging modalities showed an irregular contour and a mass-like lesion in the spinal cord. No biopsies were performed. Clinical diagnoses were suspected sarcoidosis and malignant lymphoma. The patient was treated by steroids and anti-cancer drugs, but she suddenly died of unknown cause. An autopsy revealed fibrosis and non-caseating granulomata in the spinal cord. No acid-fast bacteria or fungi were recognized by special stains. A PCR revealed no acid-fast bacteria including tuberculosis. Other organs including the brain and lung showed no sarcoidosis lesions. A pathological diagnosis of isolated spinal neurosarcoidosis was made. Other pathological diagnoses were systemic congestion, lung emphysema, food impaction in the upper esophagus and larynx, cardiac hypertrophy and marked dilation of the colon. The cause of death was thought to be respiratory failure.
We have reported a very rare autopsy case of isolated spinal neurosarcoidosis, with an emphasis on pathological findings.
孤立性脊柱神经结节病的尸检病例极为罕见或不存在。
报告一例无其他器官受累的孤立性脊柱神经结节病尸检病例。
有少数孤立性脊柱神经结节病的报告，但英文文献中尚无孤立性脊柱神经结节病的尸检病例。
日本。
对一例孤立性脊柱神经结节病的尸检病例进行病理检查。
一名 54 岁女性因下肢麻木和肌无力而入院。影像学检查显示脊髓形态不规则，呈块状病变。未进行活检。临床诊断怀疑为结节病和恶性淋巴瘤。患者接受了类固醇和抗癌药物治疗，但她突然因不明原因死亡。尸检显示脊髓纤维化和非干酪样肉芽肿。特殊染色未发现抗酸杆菌或真菌。PCR 未发现包括结核分枝杆菌在内的抗酸杆菌。脑和肺等其他器官无结节病病变。作出孤立性脊柱神经结节病的病理诊断。其他病理诊断为全身淤血、肺气肿、上食管和喉食物嵌塞、心脏肥大和结肠显著扩张。死因被认为是呼吸衰竭。
我们报告了一例非常罕见的孤立性脊柱神经结节病尸检病例，重点介绍了病理发现。
