Moll H D, Schumacher J, Wright J C, Spano J S
Department of Large Animal Medicine and Surgery, College of Veterinary Medicine, Auburn University, AL 36849-5522.
Am J Vet Res. 1991 Jan;52(1):88-91.
Twelve ponies were used to evaluate the reliability of an abdominal adhesion model and the efficacy of intraperitoneal infusion of sodium carboxymethylcellulose in preventing abdominal adhesions. A celiotomy was performed on each of the 12 ponies and the serosa of the distal portion of the jejunum was abraded with a dry gauze sponge at 5 locations. In addition to the serosal damage, a single 2-0 chromic gut suture was placed through the seromuscular layer of the jejunum in the center of the abraded area. After closure of the celiotomy, a 1% solution of sodium carboxymethylcellulose (7 ml/kg of body weight) was infused into the peritoneal cavity of 6 ponies. The other ponies served as untreated controls. All ponies were euthanatized 14 days after surgery. All ponies in the control group had abdominal adhesions at the time of necropsy. Four of the 6 ponies in the treatment group were free of adhesions. There was a significant (P less than 0.0001) difference in the total number of adhesions between the 2 groups.
选用12匹小马评估腹部粘连模型的可靠性以及腹腔内注入羧甲基纤维素钠预防腹部粘连的效果。对12匹小马逐一进行剖腹术，用干纱布海绵在空肠远端的浆膜上5个部位进行擦伤。除了浆膜损伤外，在擦伤区域中央的空肠浆肌层穿过一根2-0铬制肠缝线。关闭剖腹切口后，向6匹小马的腹腔内注入1%的羧甲基纤维素钠溶液（7毫升/千克体重）。其他小马作为未治疗的对照组。所有小马在术后14天实施安乐死。尸检时，对照组所有小马均有腹部粘连。治疗组6匹小马中有4匹未出现粘连。两组之间粘连总数存在显著差异（P小于0.0001）。
