Mueller P O, Hunt R J, Allen D, Parks A H, Hay W P
Department of Large Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens 30602, USA.
Vet Surg. 1995 Mar-Apr;24(2):112-7. doi: 10.1111/j.1532-950x.1995.tb01304.x.
The effect of intraperitoneal sodium carboxymethylcellulose (SCMC) administration on clinical outcome and survival was evaluated in horses undergoing exploratory celiotomy for acute gastrointestinal disease. Comparison of variables was made retrospectively between 44 horses that had SCMC and 92 horses (controls) not treated with SCMC. Mean age, body weight, heart rate, packed cell volume and plasma total protein of horses at admission, and convalescent period were not significantly different between control and SCMC groups. No significant differences were noted between control horses and SCMC horses with respect to incisional infection, hernia formation, recurrent episodes of colic, clinical outcome, and long-term survival (> 6 months). Seventy-six (83%) control horses and 34 (77%) SCMC horses survived long-term. Seventy (76%) control horses and 30 (68%) SCMC horses survived without complications and returned to their previous use. These results suggest that intraperitoneal use of SCMC does not adversely affect abdominal incisional wound healing, clinical outcome or long-term survival, however, the efficacy of SCMC in prevention of postoperative intestinal adhesions in horses requires further investigation.
在因急性胃肠疾病接受剖腹探查术的马匹中，评估了腹腔内注射羧甲基纤维素钠（SCMC）对临床结局和存活率的影响。对44匹接受SCMC治疗的马匹和92匹未接受SCMC治疗的马匹（对照组）的变量进行了回顾性比较。对照组和SCMC组马匹入院时及恢复期的平均年龄、体重、心率、红细胞压积和血浆总蛋白无显著差异。在切口感染、疝形成、绞痛复发、临床结局和长期存活（>6个月）方面，对照组马匹和SCMC组马匹之间未观察到显著差异。76匹（83%）对照组马匹和34匹（77%）SCMC组马匹长期存活。70匹（76%）对照组马匹和30匹（68%）SCMC组马匹无并发症存活并恢复到之前的使用状态。这些结果表明，腹腔内使用SCMC不会对腹部切口愈合、临床结局或长期存活产生不利影响，然而，SCMC在预防马匹术后肠粘连方面的疗效需要进一步研究。
