促黄体生成素（LH）和促卵泡生成素（FSH）刺激下仓鼠排卵前卵泡中环状单磷酸腺苷（cAMP）和环状单磷酸鸟苷（cGMP）的积累。

Cyclic AMP and cyclic GMP accumulation in hamster pre-ovulatory follicles stimulated with LH and FSH.

作者信息

Makris A, Ryan K J

出版信息

Acta Endocrinol (Copenh). 1978 Jan;87(1):158-63. doi: 10.1530/acta.0.0870158.

DOI:10.1530/acta.0.0870158

PMID:202132

Abstract

Cyclic AMP and cyclic GMP accumulation in hamster pre-ovulatory follicles was determined after in vitro stimulation by LH and FSH. Combined time course and dose response experiments determined that the acute response of the follicles (0-30 min) to LH and FSH was similar with respect to cyclic AMP accumulation. The pattern of cyclic GMP accumulation was, however, distinctly different in LH and FSH stimulated follicles. LH increased follicular cyclic GMP only at the lowest dose (0.005 IU/ml), while higher doses of LH had no effect. In contrast, FSH at all doses stimulated cyclic GMP accumulation. The different cyclic AMP to cyclic relationships generated in the follicles by LH and FSH may be determinants in specificity of hormone action in pre-ovulatory follicles.

摘要

在体外经促黄体生成素（LH）和促卵泡生成素（FSH）刺激后，测定了仓鼠排卵前卵泡中环状腺苷酸（cAMP）和环状鸟苷酸（cGMP）的积累情况。联合时间进程和剂量反应实验表明，卵泡（0 - 30分钟）对LH和FSH的急性反应在cAMP积累方面相似。然而，在LH和FSH刺激的卵泡中，cGMP积累模式明显不同。LH仅在最低剂量（0.005 IU/ml）时增加卵泡cGMP，而更高剂量的LH则无作用。相比之下，所有剂量的FSH均刺激cGMP积累。LH和FSH在卵泡中产生的不同cAMP与cGMP关系可能是排卵前卵泡中激素作用特异性的决定因素。