异氰化物与噻酚和偕二官能团烯烃的反应：取代 2-氨基吡啶的一锅合成法。
Reaction of isocyanides with thiophenols and gem-diactivated olefins: a one-pot synthesis of substituted 2-aminopyrroles.
机构信息
Department of Technology for Organic Synthesis, TOSLab, Ural State Technical University, 620002 Ekaterinburg, Russian Federation.
出版信息
Mol Divers. 2010 Aug;14(3):543-50. doi: 10.1007/s11030-010-9233-x. Epub 2010 Mar 7.
PMID:20213288
Abstract
A novel multicomponent reaction of isocyanides with thiophenols and gem-diactivated olefins has been discovered. Depending on the choice of isocyanides, substituted 2-aminopyrroles or thioimidates have been prepared. The obtained scaffolds bearing four points of diversity can directly be used in combinatorial syntheses.
摘要
发现了一种异氰与噻酚和偕二官能化烯烃的新的多组分反应。根据异氰的选择，可以制备取代的 2-氨基吡咯或硫代亚氨基酯。得到的具有四个多样性点的支架可以直接用于组合合成。
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