铜催化的 1-(2-碘芳基)-2-炔-1-酮与异氰化物的串联反应合成 4-氧代茚并[1,2-b]吡咯。
Copper-catalyzed tandem reactions of 1-(2-iodoary)-2-yn-1-ones with isocyanides for the synthesis of 4-oxo-indeno[1,2-b]pyrroles.
机构信息
Key Laboratory of Regenerative Biology and Institue of Chemical Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190 Kaiyuan Avenue, Guangzhou Science Park, Guangzhou, 510530, China.
出版信息
Org Lett. 2011 Jan 21;13(2):340-3. doi: 10.1021/ol102826f. Epub 2010 Dec 17.
PMID:21162591
Abstract
A novel copper-catalyzed tandem reaction of 1-(2-iodoaryl)-2-yn-1-ones with isocyanides is described. The reaction is through a formal [3 + 2] cycloaddition/coupling tandem process and leads to efficient formation of 4-oxo-indeno[1,2-b]pyrroles.
摘要
一种新型的铜催化 1-(2-碘芳基)-2-炔-1-酮与异氰化物的串联反应被描述。该反应通过一个形式上的[3+2]环加成/偶联串联过程进行，并有效地生成了 4-氧代茚并[1,2-b]吡咯。
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