无溶剂条件下一锅法合成 3,4-二氢嘧啶-2(1H)-酮的耐水性和可重复使用的路易斯酸催化剂。

Water-tolerant and reusable Lewis acid catalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions.

机构信息

College of Chemistry and Chemical Engineering, Bohai University, Jinzhou, Liaoning, P R China.

出版信息

Prep Biochem Biotechnol. 2010;40(2):101-6. doi: 10.1080/10826060903558562.

PMID:20213571

Abstract

3,4-Dihydropyrimidin-2-(1H)-ones were synthesized in high yields by a one-pot cyclocondensation of an aldehyde, a 1,3-dicarbonyl compound, and urea using copper methanesulfonate (2 mol%) as a recyclable catalyst under solvent-free conditions in short reaction time (1-2 h).

摘要

3,4-二氢嘧啶-2-(1H)-酮可以通过醛、1,3-二羰基化合物和尿素一锅法在无溶剂条件下，以铜甲烷磺酸酯（2 摩尔%）为可回收催化剂，在短时间（1-2 小时）内进行环缩合反应高产率合成。