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溴化锌在无溶剂条件下催化脂肪醛进行高效一锅法Biginelli缩合反应。

An Efficient one-pot Biginelli condensation of aliphatic aldehydes catalyzed by zinc bromide under solvent-free conditions.

作者信息

Yu Yang, Liu Di, Liu Chunsheng, Jiang Heng, Luo Genxiang

机构信息

Department of Chemistry, Liaoning University of Petroleum and Chemical Technology, Fushun, Liaoning, PR China.

出版信息

Prep Biochem Biotechnol. 2007;37(4):381-7. doi: 10.1080/10826060701593290.

DOI:10.1080/10826060701593290
PMID:17849292
Abstract

Zinc bromide catalyzes the three component condensation reaction of an aldehyde, urea, and beta-ketoester or beta-diketone under solvent-free conditions to afford the corresponding dihydropyrimidinones (DHPMs) with moderate to high yields in short reaction time. The present method is very effective for the Biginelli condensation of aliphatic aldehydes.

摘要

溴化锌在无溶剂条件下催化醛、尿素与β-酮酯或β-二酮的三组分缩合反应，在短反应时间内以中等到高的产率得到相应的二氢嘧啶酮（DHPMs）。本方法对脂肪醛的Biginelli缩合反应非常有效。

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