• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

以氯乙酸为催化剂一锅法合成3,4-二氢嘧啶-2(1H)-酮

One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones using chloroacetic acid as catalyst.

作者信息

Yu Yang, Liu Di, Liu Chunsheng, Luo Genxiang

机构信息

Department of Chemistry, Liaoning University of Petroleum and Chemical Technology, Fushun, Liaoning 113001, PR China.

出版信息

Bioorg Med Chem Lett. 2007 Jun 15;17(12):3508-10. doi: 10.1016/j.bmcl.2006.12.068. Epub 2006 Dec 23.

DOI:10.1016/j.bmcl.2006.12.068
PMID:17490874
Abstract

A simple and effective synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives from aldehydes, 1,3-dicarbonyl compounds and urea or thiourea using chloroacetic acid as catalyst under solvent-free conditions is described. Compared with the classical Biginelli reaction conditions, this new method has the advantage of good to excellent yields and short reaction time.

摘要

描述了一种在无溶剂条件下，以氯乙酸为催化剂，由醛、1,3 - 二羰基化合物与尿素或硫脲简单有效地合成3,4 - 二氢嘧啶 - 2(1H)-酮衍生物的方法。与经典的Biginelli反应条件相比，这种新方法具有产率良好至优异以及反应时间短的优点。

相似文献

1
One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones using chloroacetic acid as catalyst.以氯乙酸为催化剂一锅法合成3,4-二氢嘧啶-2(1H)-酮
Bioorg Med Chem Lett. 2007 Jun 15;17(12):3508-10. doi: 10.1016/j.bmcl.2006.12.068. Epub 2006 Dec 23.
2
Water-tolerant and reusable Lewis acid catalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions.无溶剂条件下一锅法合成 3,4-二氢嘧啶-2(1H)-酮的耐水性和可重复使用的路易斯酸催化剂。
Prep Biochem Biotechnol. 2010;40(2):101-6. doi: 10.1080/10826060903558562.
3
Copper nitrate catalyzed three-component one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones.硝酸铜催化的3,4-二氢嘧啶-2(1H)-酮的三组分一锅法合成
Prep Biochem Biotechnol. 2009;39(4):372-9. doi: 10.1080/10826060903209596.
4
One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones using CuBr2 as catalyst.以溴化铜为催化剂一锅法合成3,4-二氢嘧啶-2(1H)-酮
Prep Biochem Biotechnol. 2006;36(4):375-81. doi: 10.1080/10826060600912682.
5
Synthesis of 4-aryl-3,4-dihydropyrimidin-2(1H)-thione derivatives as potential calcium channel blockers.作为潜在钙通道阻滞剂的4-芳基-3,4-二氢嘧啶-2(1H)-硫酮衍生物的合成
Bioorg Med Chem. 2006 Dec 15;14(24):8582-9. doi: 10.1016/j.bmc.2006.08.031. Epub 2006 Sep 12.
6
Praseodymium methanesulfonate catalyzed one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones.甲磺酸镨催化一锅法合成3,4-二氢嘧啶-2-(1H)-酮
Prep Biochem Biotechnol. 2008;38(1):105-14. doi: 10.1080/10826060701774411.
7
Microwave-assisted synthesis of dihydropyrimidin-2(1H)-ones using graphite supported lanthanum chloride as a mild and efficient catalyst.以石墨负载氯化镧为温和高效催化剂微波辅助合成二氢嘧啶-2(1H)-酮
Bioorg Med Chem Lett. 2008 Jan 1;18(1):278-80. doi: 10.1016/j.bmcl.2007.10.087. Epub 2007 Oct 30.
8
Studies on the synthesis and biological activitiy of 6-ethyl-4-aryl-5-methoxycarbonyl-3,4-dihydropyrimidin-2(1H)-ones.6-乙基-4-芳基-5-甲氧基羰基-3,4-二氢嘧啶-2(1H)-酮的合成与生物活性研究
Arzneimittelforschung. 2007;57(3):137-42. doi: 10.1055/s-0031-1296596.
9
An efficient synthesis of 3,4-Dihydropyrimidin-2(1H)-ones and thiones catalyzed by a novel Brønsted acidic ionic liquid under solvent-free conditions.一种新型布朗斯特酸性离子液体在无溶剂条件下催化高效合成3,4-二氢嘧啶-2(1H)-酮和硫酮。
Molecules. 2015 Feb 26;20(3):3811-20. doi: 10.3390/molecules20033811.
10
Ultrasound promoted one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones using dendrimer-attached phosphotungstic acid nanoparticles immobilized on nanosilica.超声促进使用固定在纳米二氧化硅上的树枝状大分子连接的磷钨酸纳米颗粒一锅法合成3,4-二氢嘧啶-2(1H)-酮/硫酮
Ultrason Sonochem. 2018 Jan;40(Pt A):230-237. doi: 10.1016/j.ultsonch.2017.07.015. Epub 2017 Jul 10.

引用本文的文献

1
Synthesis, molecular docking, molecular dynamic simulation and biological evaluation of novel 3,4-dihydropyridine derivatives as potent antituberculosis agents.新型3,4-二氢吡啶衍生物作为强效抗结核药物的合成、分子对接、分子动力学模拟及生物学评价
Mol Divers. 2025 Jul 1. doi: 10.1007/s11030-025-11276-6.
2
In Melting Points We Trust: A Review on the Misguiding Characterization of Multicomponent Reactions Adducts and Intermediates.在熔点中寻找答案：对多组分反应加合物和中间体误导性特征的综述。
Molecules. 2022 Nov 4;27(21):7552. doi: 10.3390/molecules27217552.
3
Acetophenone-Based 3,4-Dihydropyrimidine-2(1H)-Thione as Potential Inhibitor of Tyrosinase and Ribonucleotide Reductase: Facile Synthesis, Crystal Structure, In-Vitro and In-Silico Investigations.
基于苯乙酮的 3,4-二氢嘧啶-2(1H)-硫酮作为酪氨酸酶和核糖核苷酸还原酶潜在抑制剂：简便合成、晶体结构、体外和计算机研究。
Int J Mol Sci. 2022 Oct 29;23(21):13164. doi: 10.3390/ijms232113164.
4
Solvothermal Synthesis of Multiple Dihydropyrimidinones at a Time as Inhibitors of Eg5.一锅法合成多种二氢嘧啶酮类化合物作为 Eg5 的抑制剂。
Molecules. 2021 Mar 30;26(7):1925. doi: 10.3390/molecules26071925.
5
Current progress in asymmetric Biginelli reaction: an update.不对称比格利希反应的最新进展：综述。
Mol Divers. 2018 Aug;22(3):751-767. doi: 10.1007/s11030-018-9841-4. Epub 2018 Jun 23.
6
An Efficient, Eco-friendly and Sustainable One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Directly from Alcohols Catalyzed by Heteropolyanion-Based Ionic Liquids.杂多阴离子基离子液体催化醇直接一锅法高效、环保、可持续合成 3,4-二氢嘧啶-2(1H)-酮。
Molecules. 2017 Sep 11;22(9):1531. doi: 10.3390/molecules22091531.
7
Synthesis, spectral characterization and analgesic activity of 2-methylthio-1,4-dihydropyrimidines.2-甲硫基-1,4-二氢嘧啶的合成、光谱表征及镇痛活性
Iran J Pharm Res. 2011 Fall;10(4):733-9.
8
Three Component Reaction: An Efficient Synthesis and Reactions of 3,4-Dihydropyrimidin-2(1H)-Ones and Thiones Using New Natural Catalyst.三组分反应：使用新型天然催化剂高效合成3,4-二氢嘧啶-2(1H)-酮和硫酮及其反应
ISRN Org Chem. 2013 Aug 18;2013:706437. doi: 10.1155/2013/706437. eCollection 2013.
9
Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and Their Corresponding 2(1H)Thiones Using Trichloroacetic Acid as a Catalyst under Solvent-Free Conditions.在无溶剂条件下以三氯乙酸为催化剂合成3,4-二氢嘧啶-2(1H)-酮及其相应的2(1H)-硫酮
ISRN Org Chem. 2012 Oct 15;2012:474626. doi: 10.5402/2012/474626. eCollection 2012.
10
A Green, Expeditious, One-Pot Synthesis of 3, 4-Dihydropyrimidin-2(1H)-ones Using a Mixture of Phosphorus Pentoxide-Methanesulfonic Acid at Ambient Temperature.室温下使用五氧化二磷-甲磺酸混合物快速绿色一锅法合成3,4-二氢嘧啶-2(1H)-酮
ISRN Org Chem. 2012 Aug 8;2012:415645. doi: 10.5402/2012/415645. eCollection 2012.