Department of Experimental Oncology, Division of Hematology, University of Torino, Italy.
Hematol Oncol. 2010 Dec;28(4):157-67. doi: 10.1002/hon.937.
The telomeric checkpoint is emerging as a critical sensor of cellular damage, playing a major role in human aging and cancer development. In the meantime, telomere biology is rapidly evolving from a basic discipline to a translational branch, capable of providing major hints for biomarker development, risk assessment and targeted treatment of cancer. These advances have a number of implications in the biology of lymphoid tumours. Moreover, there is considerable interest in the potential role of telomeric dysfunction in the wide array of immunological abnormalities, grouped under the definition of 'immunosenescence'. This review will summarize the impact of recent advances in telomere biology on the physiology and pathology of the B lymphocyte, with special interest in immunosenescence and lymphomagenesis.
端粒检查点正在成为细胞损伤的关键传感器，在人类衰老和癌症发展中发挥着重要作用。与此同时，端粒生物学正迅速从一个基础学科发展成为一个转化分支，能够为生物标志物的开发、风险评估和癌症的靶向治疗提供重要线索。这些进展对淋巴肿瘤的生物学有许多影响。此外，人们对端粒功能障碍在广泛的免疫异常中的潜在作用非常感兴趣，这些免疫异常被归为“免疫衰老”的定义之下。这篇综述将总结端粒生物学的最新进展对 B 淋巴细胞的生理学和病理学的影响，特别关注免疫衰老和淋巴瘤发生。
