Gunes Sezgin, Hekim Gulgez Neslihan Taskurt, Arslan Mehmet Alper, Asci Ramazan
Faculty of Medicine, Department of Medical Biology, Ondokuz Mayis University, 55139, Samsun, Turkey.
Health Sciences Institute, Department of Multidisciplinary Molecular Medicine, Ondokuz Mayis University, Samsun, Turkey.
J Assist Reprod Genet. 2016 Apr;33(4):441-54. doi: 10.1007/s10815-016-0663-y. Epub 2016 Feb 11.
The study aims to discuss the effects of aging on the male reproductive system. A systematic review was performed using PubMed from 1980 to 2014. Aging is a natural process comprising of irreversible changes due to a myriad of endogenous and environmental factors at the level of all organs and systems. In modern life, as more couples choose to postpone having a child due to various socioeconomic reasons, research for understanding the effects of aging on the reproductive system has gained an increased importance. Paternal aging also causes genetic and epigenetic changes in spermatozoa, which impair male reproductive functions through their adverse effects on sperm quality and count as, well as, on sexual organs and the hypothalamic-pituitary-gonadal axis. Hormone production, spermatogenesis, and testes undergo changes as a man ages. These small changes lead to decrease in both the quality and quantity of spermatozoa. The offspring of older fathers show high prevalence of genetic abnormalities, childhood cancers, and several neuropsychiatric disorders. In addition, the latest advances in assisted reproductive techniques give older men a chance to have a child even with poor semen parameters. Further studies should investigate the onset of gonadal senesce and its effects on aging men.
该研究旨在探讨衰老对男性生殖系统的影响。利用PubMed对1980年至2014年的文献进行了系统综述。衰老是一个自然过程，在所有器官和系统层面，由于无数内源性和环境因素，会发生不可逆转的变化。在现代生活中，由于各种社会经济原因，越来越多的夫妇选择推迟生育，因此了解衰老对生殖系统影响的研究变得越发重要。父亲年龄的增长也会导致精子发生基因和表观遗传变化，这些变化通过对精子质量、数量以及性器官和下丘脑 - 垂体 - 性腺轴产生不利影响，损害男性生殖功能。随着男性年龄的增长，激素分泌、精子发生以及睾丸都会发生变化。这些微小变化会导致精子质量和数量下降。年长父亲的后代出现遗传异常、儿童期癌症和几种神经精神疾病的患病率较高。此外，辅助生殖技术的最新进展使精液参数不佳的老年男性也有机会生育。进一步的研究应调查性腺衰老的起始及其对老年男性的影响。
