Department of Nuclear Medicine, St. Paul's Hospital & University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada.
Expert Rev Anticancer Ther. 2010 Mar;10(3):353-63. doi: 10.1586/era.10.11.
Primary hyperparathyroidism, most commonly due to a solitary parathyroid adenoma, has become an increasingly diagnosed condition and is one with great potential for cure following appropriate surgical intervention. Functional imaging with Tc-99m-based radiopharmaceuticals has contributed significantly to increased success in preoperative adenoma localization but the advent of fusion of this functional information with anatomical details obtained with computed tomographic imaging has yielded a potentially more powerful clinical tool and one that is particularly well suited to ectopic adenomas and cases of prior failed surgery. Aspects of this modality are discussed with reference to software- and hardware-based fusion techniques and evidence for efficacy. The allied technique of PET/computed tomography is also discussed.
原发性甲状旁腺功能亢进症，最常见的原因是甲状旁腺瘤，已经成为一种越来越常见的诊断疾病，并且在适当的手术干预后，有很大的治愈潜力。使用 Tc-99m 放射性药物进行功能成像极大地提高了术前腺瘤定位的成功率，但这种功能信息与 CT 成像获得的解剖细节融合的出现，提供了一种更强大的临床工具，特别适用于异位腺瘤和先前手术失败的病例。本文将讨论该方法的各个方面，包括基于软件和硬件的融合技术以及疗效证据。同时还讨论了与之相关的正电子发射断层扫描/计算机断层扫描技术。
