Department of Virology, Norwegian Institute of Public Health, Oslo, Norway.
Euro Surveill. 2010 Mar 4;15(9):19498. doi: 10.2807/ese.15.09.19498-en.
Infection with the recently emerged pandemic influenza A(H1N1) virus causes mild disease in the vast majority of cases, but sporadically also very severe disease. A specific mutation in the viral haemagglutinin (D222G) was found with considerable frequency in fatal and severe cases in Norway, but was virtually absent among clinically mild cases. This difference was statistically significant and our data are consistent with a possible causal relationship between this mutation and the clinical outcome.
最近出现的大流行流感 A(H1N1) 病毒感染在绝大多数情况下导致轻度疾病，但偶尔也会导致非常严重的疾病。在挪威的致命和严重病例中，发现病毒血凝素（D222G）的一个特定突变相当频繁，但在临床轻度病例中几乎不存在。这种差异具有统计学意义，我们的数据与该突变与临床结果之间可能存在因果关系一致。
