Unit Virology, Microbiology Laboratory, Charles Nicolle's Hospital, National Influenza Centre-Tunis, Tunis, Tunisia.
Arch Virol. 2012 Sep;157(9):1813-4. doi: 10.1007/s00705-012-1349-0. Epub 2012 Jun 9.
Recently, the D222G substitution was observed in the HA of pandemic (H1N1) 2009 viruses isolated from fatal cases in several countries. We made a similar observation in one fatal case in Tunisia showing a D222G substitution in a virus isolate. The man was 47 years old and had no other subjacent pathologies or any known risk factors. He died after three days, suffering from severe respiratory symptoms of flu. The causal link of the D222G substitution in Tunisia with virulence must be verified. Further study is warranted to elucidate the intriguing relationship between the D222G substitution and severe disease. Constant molecular surveillance is important to monitor the pathogenicity of circulating strains and evaluate vaccine efficacy.
最近，在来自多个国家的致命病例中分离出的大流行性（H1N1）2009 病毒的 HA 中观察到 D222G 取代。我们在突尼斯的一个致命病例中也观察到了类似的情况，病毒分离株中存在 D222G 取代。该男子 47 岁，没有其他潜在的病理学或任何已知的危险因素。他在感染流感后三天因严重的呼吸道症状而死亡。突尼斯 D222G 取代与毒力之间的因果关系必须得到验证。需要进一步研究来阐明 D222G 取代与严重疾病之间的有趣关系。持续的分子监测对于监测流行株的致病性和评估疫苗效果非常重要。
