Research Group Emerging Zoonoses, Robert Koch-Institute, Nordufer 20, 13353 Berlin, Germany.
Virus Res. 2010 Jun;150(1-2):143-7. doi: 10.1016/j.virusres.2010.02.020. Epub 2010 Mar 7.
Simian T-lymphotropic viruses type 1 (STLV-1) are regarded as a highly conserved group of viruses with genotypes clustering according to geographic regions rather than to infected species. In free living West African chimpanzees we have described a variety of STLV-1 strains and suggested that this diversity results from interspecies transmissions. Here we present new data on STLV-1 infections in these chimpanzees with the presence of two new distinct clades, proposing the establishing of two new STLV-1 subtypes. Moreover, in one of the chimpanzees, the Central African STLV-1 subtype B was detected. The STLV-1 strains detected here display a much wider diversity than heretofore reported for STLV-1 with presence of three distinct subtypes in chimpanzees from one distinct geographic region. In conclusion, the hypothesis of primate T-lymphotropic virus type 1 (PTLV-1) clustering by geography rather than host should be reconsidered, at least regarding STLV-1 infections in chimpanzees.
猿猴 T 淋巴细胞病毒 1 型（STLV-1）被认为是一组高度保守的病毒，其基因型根据地理区域聚类，而不是根据感染的物种聚类。在自由生活的西非黑猩猩中，我们描述了多种 STLV-1 株，并提出这种多样性是由种间传播引起的。在这里，我们提出了有关这些黑猩猩中 STLV-1 感染的新数据，其中存在两个新的不同分支，提出建立两个新的 STLV-1 亚型。此外，在其中一只黑猩猩中，检测到了中非 STLV-1 亚型 B。这里检测到的 STLV-1 株显示出比以前报道的 STLV-1 更大的多样性，在一个独特的地理区域的黑猩猩中存在三种不同的亚型。总之，至少在涉及黑猩猩的 STLV-1 感染方面，应重新考虑按地理而不是宿主对灵长类 T 淋巴细胞病毒 1 型（PTLV-1）进行聚类的假设。
