Queen's Medical Research Institute, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
Reproduction. 2010 Sep;140(3):373-85. doi: 10.1530/REP-10-0074. Epub 2010 Mar 9.
Maternal obesity is associated with increased morbidity and mortality for both mother and offspring. The mechanisms underlying the increased risk associated with maternal obesity are not well understood. In non-pregnant populations, many of the complications of obesity are thought to be mediated in part by inflammation and its sequelae. Recent studies suggest that a heightened inflammatory response may also be involved in mediating adverse clinical outcomes during pregnancy. This review summarizes our current knowledge about adipose tissue biology, and its role as an endocrine and inflammatory organ. The evidence for inflammation as a key mediator of adverse pregnancy outcome is also presented, focusing on the role of inflammation in adipose tissue, systemic inflammation, the placenta, and vascular endothelium.
母体肥胖与母婴发病率和死亡率的增加有关。母体肥胖相关风险增加的潜在机制尚不清楚。在非妊娠人群中，肥胖的许多并发症被认为部分是由炎症及其后果介导的。最近的研究表明，在怀孕期间，强烈的炎症反应也可能参与调节不良的临床结局。这篇综述总结了我们目前对脂肪组织生物学及其作为内分泌和炎症器官的作用的认识。还提出了炎症作为不良妊娠结局的关键介质的证据，重点介绍了炎症在脂肪组织、全身炎症、胎盘和血管内皮中的作用。
