Kim Hyung-Jin, Kim Yong-Baek, Park Jun-Won, Oh Won-Seok, Kim Eun-Ok, Lim Byoung-Yong, Kim Dae-Yong
Department of Veterinary Pathology, Seoul National University, Seoul, South Korea.
J Vet Med Sci. 2010 Jul;72(7):947-9. doi: 10.1292/jvms.09-0521. Epub 2010 Mar 9.
A 1.5-year-old intact male African hedgehog (Atelerix albiventris) was presented with a firm, non-movable subcutaneous mass on ventral chest area. Microscopically, the tumor was un-encapsulated, invasive up to the muscle layer, and composed of highly pleomorphic polygonal cells arranged in variably-sized lobules. The neoplastic cells had abundant cytoplasm with vacuolation and a large pleomorphic nucleus with prominent nucleoli. Mitotic figures were frequently observed with atypical mitoses. Immunohistochemically, the neoplastic cells were strongly positive for cytokeratin, but negative for vimentin. Based on these findings, a diagnosis of sebaceous carcinoma was made. Three months after the surgery, a recurrent mass was found at the surgical site. On necropsy, the mass has penetrated the underlying intercostal musculature, without metastasis to distant organs. This is the first report of a sebaceous carcinoma in an African hedgehog.
一只1.5岁未绝育的雄性非洲刺猬（南非刺猬）因胸部腹侧出现一个坚硬、不可移动的皮下肿块前来就诊。显微镜下，肿瘤无包膜，侵犯至肌肉层，由排列成大小不一小叶的高度多形性多边形细胞组成。肿瘤细胞有丰富的含空泡的细胞质以及一个有明显核仁的大的多形性细胞核。经常观察到有丝分裂象，包括非典型有丝分裂。免疫组化显示，肿瘤细胞细胞角蛋白呈强阳性，波形蛋白呈阴性。基于这些发现，诊断为皮脂腺癌。手术后三个月，在手术部位发现复发性肿块。尸检时，肿块已穿透下方的肋间肌肉组织，未发生远处器官转移。这是非洲刺猬皮脂腺癌的首例报告。
